Product Information:

ZOLIGET 30mg/4mg Tablets is a fixed-dose combination of two oral antidiabetic agents:

1. Pioglitazone Hydrochloride 30mg – a thiazolidinedione (TZD) that enhances insulin sensitivity in muscle, fat, and liver by activating PPAR-γ receptors
2. Glimepiride 4mg – a second-generation sulfonylurea that stimulates insulin secretion from pancreatic beta cells

This higher-strength dual therapy is intended for adults with type 2 diabetes mellitus who require more intensive glycemic control due to inadequate response to lower doses of either component.

Uses of (ZOLIGET 30MG/4MG TABLETS):

1. Management of type 2 diabetes mellitus in adults
2. Patients uncontrolled on pioglitazone 30mg + glimepiride 2mg or other dual therapies
3. Those needing stronger insulin secretion and sensitization in a single tablet

Key Benefits of (ZOLIGET 30MG/4MG TABLETS):

1. Dual mechanism targets both insulin resistance and deficient insulin secretion
2. Glimepiride 4mg provides robust postprandial glucose control
3. Pioglitazone 30mg improves fasting glucose and long-term insulin sensitivity
4. Once-daily dosing reduces pill burden and supports adherence

How To Use (ZOLIGET 30MG/4MG TABLETS):

1. Take once daily with breakfast or the first main meal to reduce hypoglycemia risk.
2. Swallow whole with water—do not crush or chew.
3. Do not skip meals while on this medication.
4. Continue diet, exercise, and regular blood glucose monitoring.

When Not to Use (ZOLIGET 30MG/4MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe hepatic or renal impairment
3. History of bladder cancer (pioglitazone increases risk)
4. Heart failure (NYHA Class III or IV)
5. Hypersensitivity to pioglitazone, glimepiride, or other sulfonylureas

⚠️ Important: The 4mg glimepiride dose carries a higher risk of hypoglycemia, especially in elderly or malnourished patients.

Side Effects of (ZOLIGET 30MG/4MG TABLETS):

Common:

1. Hypoglycemia (sweating, dizziness, tremor, confusion, palpitations)—more likely than with 2mg glimepiride
2. Weight gain (from both components)
3. Peripheral edema (ankle/leg swelling)
4. Headache, nausea

Less common:

1. Bone fractures (pioglitazone—especially in postmenopausal women)
2. Photosensitivity (glimepiride)
3. Mild anemia or elevated liver enzymes

Serious (rare but require immediate attention):

1. Severe hypoglycemia (loss of consciousness, seizures)—requires emergency glucose
2. Worsening heart failure (shortness of breath, rapid weight gain, fatigue)
3. Bladder cancer (hematuria, urinary urgency, pelvic pain)—risk increases with pioglitazone duration >1 year
4. Hepatotoxicity (jaundice, dark urine, abdominal pain)
5. Seek emergency care if severe hypoglycemia, heart failure symptoms, or blood in urine occur.

Dosage: (ZOLIGET 30MG/4MG TABLETS):

1. Adults: 1 tablet once daily with breakfast
2. Maximum daily dose: Pioglitazone 45mg + Glimepiride 8mg
3. Elderly or hepatic/renal impairment: Avoid or use with extreme caution—higher hypoglycemia risk

Who It’s For (ZOLIGET 30MG/4MG TABLETS):

Adults with moderately uncontrolled type 2 diabetes who have failed lower-dose combinations and can adhere to regular meals and glucose monitoring, with no contraindications to TZDs or sulfonylureas.

Warnings & Precautions:

1. Monitor blood glucose frequently, especially during initiation
2. Avoid alcohol—increases hypoglycemia risk and masks symptoms
3. Assess for heart failure signs and bladder cancer symptoms regularly
4. Use extra caution in elderly, underweight, or renally impaired patients
5. Educate patients on hypoglycemia recognition and emergency management

Drug Interactions:

1. Beta-blockers: May mask tachycardia during hypoglycemia
2. NSAIDs, salicylates, sulfonamides: ↑ Risk of hypoglycemia
3. Rifampin: ↓ Glimepiride efficacy—monitor glucose closely
4. Gemfibrozil: ↑ Pioglitazone levels—avoid combination
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.