Product Information:

AMCLAV PLUS Suspension 457mg/5mL is a high-strength antibiotic formulation containing Amoxicillin (400mg/5mL) and Clavulanic Acid (57mg/5mL). This potent combination effectively treats moderate to severe bacterial infections by inhibiting bacterial cell wall synthesis (Amoxicillin) while overcoming beta-lactamase-mediated resistance (Clavulanic Acid). It is formulated as an oral suspension for ease of administration in children and adults who have difficulty swallowing tablets.

Uses of (AMCLAV PLUS SUSP 457MG/5ML):

AMCLAV PLUS is indicated for respiratory tract infections (e.g., pneumonia, bronchitis, sinusitis), otitis media, urinary tract infections (UTIs), skin and soft tissue infections, dental abscesses, and bone/joint infections caused by susceptible beta-lactamase-producing bacteria.

Key Benefits of (AMCLAV PLUS SUSP 457MG/5ML):

1. Broad-spectrum coverage against resistant pathogens
2. High amoxicillin concentration for severe infections
3. Clavulanic acid restores efficacy against resistant strains
4. Suitable for pediatric and adult patients unable to take tablets
5. Once- or twice-daily dosing improves compliance

How To Use (AMCLAV PLUS SUSP 457MG/5ML):

Shake the bottle well before each use. Administer with food to minimize gastrointestinal side effects. Dosage is based on body weight and infection severity—typically 20–45 mg/kg/day of amoxicillin component divided every 8–12 hours. Use the calibrated measuring spoon or syringe provided. Complete the full course even if symptoms improve early.

When Not to Use (AMCLAV PLUS SUSP 457MG/5ML):

Do not use in patients with a history of hypersensitivity to penicillins, cephalosporins, or clavulanate. Contraindicated in those with a previous episode of amoxicillin/clavulanate-associated cholestatic jaundice or hepatic dysfunction. Avoid in mononucleosis due to high risk of rash.

Side Effects of (AMCLAV PLUS SUSP 457MG/5ML):

Common: Diarrhea, nausea, vomiting, abdominal discomfort, and mild rash.

Serious (rare): Allergic reactions (anaphylaxis), Clostridioides difficile-associated colitis, hepatitis, jaundice, or Stevens-Johnson syndrome. Discontinue immediately and seek medical help if signs of liver injury (yellow skin/eyes, dark urine) or severe diarrhea occur.

Dosage: (AMCLAV PLUS SUSP 457MG/5ML):

For children ≥3 months:

1. Mild infection: 25 mg/kg/day amoxicillin in two divided doses
2. Severe infection: 45 mg/kg/day in two divided doses
3. Example: A 20 kg child with severe infection may receive 5 mL twice daily (providing 400mg amoxicillin + 57mg clavulanate per dose).
4. Adults: Typically 5 mL twice daily for severe infections. Always follow physician guidance.

Who It’s For (AMCLAV PLUS SUSP 457MG/5ML):

Designed for children (≥3 months) and adults requiring high-dose amoxicillin-clavulanate therapy, especially when tablet form is impractical. Ideal for recurrent or complicated infections where enhanced antibacterial coverage is needed.

Warnings & Precautions:

Use cautiously in patients with renal impairment (dose adjustment may be needed). Monitor for signs of superinfection or allergic reactions. Prolonged use may cause fungal overgrowth. Refrigerate after reconstitution and discard after 7–10 days. Avoid in patients with history of drug-induced liver injury.

Drug Interactions:

May reduce efficacy of oral contraceptives. Increases risk of methotrexate toxicity. Concurrent use with allopurinol raises rash risk. Probenecid can increase amoxicillin levels. Inform your doctor about all medications, including herbal supplements.

Additional Information:

Store dry powder below 25°C. After mixing with water, refrigerate (2–8°C) and use within 7–10 days. Keep tightly closed and out of reach of children. Shake well before each dose. Available by prescription only in Pakistan.