Product Information:

AMCLAV 375mg Tablets contain a fixed-dose combination of Amoxicillin (250mg) and Clavulanic Acid (125mg), offering broad-spectrum antibacterial activity. This formulation is designed for the treatment of mild to moderate bacterial infections. Amoxicillin inhibits bacterial cell wall synthesis, while Clavulanic Acid blocks beta-lactamase enzymes that would otherwise inactivate amoxicillin, thereby extending its spectrum against resistant organisms.

Uses of (AMCLAV 375MG TABLETS):

AMCLAV 375mg Tablets are used to treat respiratory tract infections (e.g., bronchitis, sinusitis, pharyngitis), urinary tract infections (UTIs), skin and soft tissue infections, otitis media, and dental abscesses caused by susceptible bacteria. It is commonly prescribed when standard amoxicillin is likely to fail due to resistance.

Key Benefits of (AMCLAV 375MG TABLETS):

1. Effective against beta-lactamase-producing resistant bacteria
2. Suitable for mild to moderate community-acquired infections
3. Three-times-daily dosing ensures sustained therapeutic levels
4. Well-established safety profile in adults and older children
5. Cost-effective option for common bacterial infections

How To Use (AMCLAV 375MG TABLETS):

Take one tablet every 8 hours (three times daily) with food to minimize stomach upset. Swallow whole with water—do not crush or chew. Complete the full course as prescribed, even if symptoms improve early, to prevent relapse and antibiotic resistance.

When Not to Use (AMCLAV 375MG TABLETS):

Do not use if you have a known allergy to penicillins, cephalosporins, or clavulanic acid. Avoid in patients with a history of amoxicillin/clavulanate-associated liver injury or cholestatic jaundice. Contraindicated in infectious mononucleosis due to high risk of rash.

Side Effects of (AMCLAV 375MG TABLETS):

Common: Diarrhea, nausea, vomiting, abdominal pain, and mild skin rash.

Rare but serious: Allergic reactions (anaphylaxis), Clostridioides difficile colitis, hepatitis, jaundice, or severe cutaneous reactions. Discontinue immediately and seek medical help if you experience yellowing of eyes/skin, severe diarrhea, or breathing difficulty.

Dosage: (AMCLAV 375MG TABLETS):

Standard adult dose: One tablet (250mg/125mg) three times daily for 5–14 days, depending on infection type. In renal impairment (CrCl <30 mL/min), reduce frequency to once or twice daily. Always follow your physician’s instructions.

Who It’s For (AMCLAV 375MG TABLETS):

Intended for adults and children weighing ≥40 kg (typically ≥12 years) with mild to moderate bacterial infections. Not recommended for younger children or those requiring lower-dose formulations.

Warnings & Precautions:

Use cautiously in patients with renal or hepatic impairment, asthma, or history of allergies. Prolonged use may lead to fungal overgrowth or antibiotic-associated colitis. Monitor for signs of superinfection. Inform your doctor if you have gastrointestinal disease or are pregnant/breastfeeding.

Drug Interactions:

May reduce effectiveness of oral contraceptives. Increases risk of methotrexate toxicity. Allopurinol co-administration raises rash incidence. Probenecid can elevate amoxicillin levels. Disclose all medications to your healthcare provider.

Additional Information:

Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children. Do not use after the expiration date on the blister pack. Available by prescription only in Pakistan.