Product Information:

AMCLAV 1gm Tablets contain a high-dose combination of Amoxicillin (875mg) and Clavulanic Acid (125mg), formulated for the treatment of moderate to severe bacterial infections in adults and adolescents. This potent broad-spectrum antibiotic works by inhibiting bacterial cell wall synthesis (Amoxicillin) while Clavulanic Acid protects it from degradation by beta-lactamase enzymes, thereby extending its effectiveness against resistant strains.

Uses of (AMCLAV 1GM TABLETS):

AMCLAV 1gm Tablets are indicated for respiratory tract infections (e.g., pneumonia, acute bronchitis, sinusitis), urinary tract infections (UTIs), skin and soft tissue infections, dental abscesses, and bone/joint infections caused by susceptible beta-lactamase-producing bacteria. It is also used in recurrent or complicated infections where enhanced antibacterial coverage is required.

Key Benefits of (AMCLAV 1GM TABLETS):

1. High amoxicillin concentration for serious infections
2. Effective against penicillin-resistant pathogens
3. Twice-daily dosing improves patient compliance
4. Proven clinical efficacy in community and hospital settings
5. Reduces risk of treatment failure compared to amoxicillin alone

How To Use (AMCLAV 1GM TABLETS):

Take one tablet every 12 hours with food to enhance absorption and reduce gastrointestinal side effects. Swallow whole with water—do not crush or chew. Complete the full prescribed course, even if symptoms improve early, to prevent antibiotic resistance and relapse.

When Not to Use (AMCLAV 1GM TABLETS):

Do not use if you have a known allergy to penicillins, cephalosporins, or clavulanic acid. Contraindicated in patients with a history of amoxicillin/clavulanate-associated cholestatic jaundice or severe hepatic dysfunction. Avoid in infectious mononucleosis due to high risk of rash.

Side Effects of (AMCLAV 1GM TABLETS):

Common: Diarrhea, nausea, vomiting, abdominal discomfort, and oral thrush.

Serious (rare): Allergic reactions (anaphylaxis), Clostridioides difficile-associated colitis, hepatitis, jaundice, or severe skin reactions (e.g., Stevens-Johnson syndrome). Discontinue immediately and seek medical help if yellowing of skin/eyes, persistent watery stools, or breathing difficulty occurs.

Dosage: (AMCLAV 1GM TABLETS):

Standard adult dose: One tablet (875mg/125mg) every 12 hours for 5–14 days, depending on infection type and severity. In severe renal impairment (CrCl <30 mL/min), dosage should be reduced to once daily. Always follow your physician’s prescription.

Who It’s For (AMCLAV 1GM TABLETS):

Intended for adults and adolescents (≥12 years and ≥40 kg) with moderate to severe bacterial infections requiring high-dose amoxicillin-clavulanate therapy. Not suitable for children under 12 or patients with significant liver disease.

Warnings & Precautions:

Use cautiously in patients with renal or hepatic impairment. Monitor for signs of superinfection or allergic reactions. Prolonged use may cause fungal overgrowth or antibiotic-associated diarrhea. Inform your doctor if you have a history of asthma, allergies, or gastrointestinal disease.

Drug Interactions:

May reduce the effectiveness of oral contraceptives. Increases risk of methotrexate toxicity. Co-administration with allopurinol raises the likelihood of skin rash. Probenecid can increase amoxicillin blood levels. Always disclose all medications to your healthcare provider.

Additional Information:

Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the blister pack. Available by prescription only in Pakistan.