Product Information:

ADVANTEC 16/12.5mg Tablets is a fixed-dose combination of Betahistine Dihydrochloride (16mg) and Cinnarizine (12.5mg), two active ingredients that work synergistically to manage vertigo and vestibular disorders. Betahistine improves inner ear microcirculation and modulates histamine receptors, while Cinnarizine acts as a calcium channel blocker and antihistamine with strong anti-vertigo and anti-emetic properties. This dual-action formula provides comprehensive relief from dizziness, tinnitus, nausea, and imbalance associated with Ménière’s disease and other vestibular conditions.

Uses of (ADVANTEC 16/12.5MG TABLETS):

ADVANTEC 16/12.5mg Tablets are used for the treatment of vertigo, motion sickness, tinnitus, hearing disturbances, and nausea linked to peripheral and central vestibular dysfunction. It is particularly effective in managing recurrent vertigo episodes and improving stability in patients with chronic labyrinthine disorders.

Key Benefits of (ADVANTEC 16/12.5MG TABLETS):

1. Dual mechanism targets both vascular and neurological causes of vertigo
2. Rapid reduction in dizziness and associated nausea
3. Improves balance and reduces fall risk in elderly patients
4. Alleviates tinnitus and auditory pressure
5. Convenient once- or twice-daily dosing for better compliance

How To Use (ADVANTEC 16/12.5MG TABLETS):

Take ADVANTEC 16/12.5mg Tablets orally with food to minimize gastric upset. The usual adult dose is one tablet two to three times daily, as directed by your physician. Swallow whole with water—do not crush or chew. Continue therapy for the prescribed duration, even if symptoms improve early. Do not discontinue abruptly without medical advice.

When Not to Use (ADVANTEC 16/12.5MG TABLETS):

Avoid use if you are allergic to betahistine, cinnarizine, or any excipients. Contraindicated in patients with Parkinson’s disease, pheochromocytoma, or active peptic ulcer disease. Not recommended during pregnancy, breastfeeding, or in children under 18 unless specifically advised by a neurologist or ENT specialist.

Side Effects of (ADVANTEC 16/12.5MG TABLETS):

Common side effects include drowsiness, dry mouth, mild gastrointestinal discomfort, and fatigue. Less common but serious effects may include extrapyramidal symptoms (e.g., tremors, rigidity—especially with long-term cinnarizine use), weight gain, or depression. Discontinue and consult a doctor if you experience muscle stiffness, uncontrolled movements, or severe drowsiness.

Dosage: (ADVANTEC 16/12.5MG TABLETS):

Standard dosage: one tablet (16/12.5mg) two to three times daily. Elderly patients may start with a lower frequency (e.g., twice daily) due to increased sensitivity to cinnarizine’s sedative effects. Maximum duration should be evaluated periodically to avoid long-term neurological side effects. Always follow your doctor’s instructions.

Who It’s For (ADVANTEC 16/12.5MG TABLETS):

Intended for adults suffering from moderate to severe vertigo, motion sickness, or chronic vestibular imbalance unresponsive to monotherapy. Particularly beneficial for patients requiring both circulatory support (via betahistine) and symptomatic control (via cinnarizine). Not suitable for children or patients with Parkinsonism.

Warnings & Precautions:

Cinnarizine may cause drowsiness or impair motor coordination—avoid driving or operating machinery. Long-term use (>3 months) may rarely lead to drug-induced parkinsonism, especially in the elderly. Use cautiously in patients with liver impairment, depression, or glaucoma. Regular reassessment is recommended during prolonged therapy.

Drug Interactions:

May enhance CNS depression when taken with alcohol, benzodiazepines, or opioids. Cinnarizine can interact with antipsychotics (increasing extrapyramidal risk) and MAOIs (risk of hypertensive crisis with betahistine). Inform your doctor about all medications, including OTC and herbal products.

Additional Information:

Store ADVANTEC 16/12.5mg Tablets below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Check expiry date on the blister pack. Available by prescription in Pakistan.