Product Information:

ZOLIGET 30mg/2mg Tablets is a fixed-dose combination of two oral antidiabetic agents:

1. Pioglitazone Hydrochloride 30mg – a thiazolidinedione (TZD) that enhances insulin sensitivity in muscle, fat, and liver by activating PPAR-γ receptors
2. Glimepiride 2mg – a second-generation sulfonylurea that stimulates insulin secretion from pancreatic beta cells

This dual-mechanism therapy addresses both insulin resistance and impaired insulin secretion, offering improved glycemic control in adults with type 2 diabetes mellitus who are not adequately managed on monotherapy.

Uses of (ZOLIGET 30MG/2MG TABLETS):

1. Management of type 2 diabetes mellitus in adults
2. Patients inadequately controlled on pioglitazone 15mg or glimepiride 2mg alone
3. Those requiring intensified dual therapy with once-daily convenience

Key Benefits of (ZOLIGET 30MG/2MG TABLETS):

1. Dual action targets both fasting and postprandial hyperglycemia
2. Pioglitazone 30mg provides stronger insulin sensitization than 15mg
3. Glimepiride 2mg offers consistent insulin release with low hypoglycemia risk at this dose
4. Once-daily dosing improves adherence and reduces pill burden

How To Use (ZOLIGET 30MG/2MG TABLETS):

1. Take once daily with breakfast or the first main meal to minimize hypoglycemia risk.
2. Swallow whole with water—do not crush or chew.
3. Maintain regular meal times and avoid skipping meals.
4. Continue diet, exercise, and regular blood glucose monitoring.

When Not to Use (ZOLIGET 30MG/2MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe hepatic or renal impairment
3. History of bladder cancer (pioglitazone increases risk)
4. Heart failure (NYHA Class III or IV)
5. Hypersensitivity to pioglitazone, glimepiride, or other sulfonylureas

⚠️ Important: Glimepiride can cause hypoglycemia—avoid alcohol and ensure consistent carbohydrate intake.

Side Effects of (ZOLIGET 30MG/2MG TABLETS):

Common:

1. Hypoglycemia (sweating, dizziness, tremor, confusion)—especially if meals are delayed or skipped
2. Weight gain (dose-dependent from pioglitazone)
3. Mild peripheral edema (ankle/leg swelling)
4. Headache, nausea

Less common:

1. Bone fractures (pioglitazone—particularly in postmenopausal women)
2. Photosensitivity (glimepiride)
3. Mild anemia or elevated liver enzymes

Serious (rare but require immediate attention):

1. Severe hypoglycemia (loss of consciousness, seizures)—requires emergency glucose administration
2. Worsening heart failure (shortness of breath, rapid weight gain, fatigue)
3. Bladder cancer (hematuria, urinary urgency, pelvic pain)—risk increases with pioglitazone duration >1 year
4. Hepatotoxicity (jaundice, dark urine, abdominal pain)
5. Seek emergency care if severe hypoglycemia, heart failure symptoms, or blood in urine occur.

Dosage: (ZOLIGET 30MG/2MG TABLETS):

1. Adults: 1 tablet once daily with breakfast
2. Maximum daily dose: Pioglitazone 45mg + Glimepiride 8mg
3. Elderly or hepatic/renal impairment: Use with caution; may require dose reduction

Who It’s For (ZOLIGET 30MG/2MG TABLETS):

Adults with type 2 diabetes who need stronger insulin-sensitizing effects than 15mg pioglitazone provides, combined with reliable insulin stimulation, and who can maintain regular meal schedules to mitigate hypoglycemia risk.

Warnings & Precautions:

1. Monitor blood glucose regularly, especially during initiation or dose changes
2. Avoid alcohol—increases risk and masks hypoglycemia symptoms
3. Assess for signs of heart failure and bladder cancer periodically
4. Use extra caution in elderly patients (higher hypoglycemia and fall risk)
5. Educate patients on hypoglycemia recognition and management

Drug Interactions:

1. Beta-blockers: May mask tachycardia during hypoglycemia
2. NSAIDs, salicylates, sulfonamides: ↑ Risk of hypoglycemia
3. Rifampin: ↓ Glimepiride efficacy—monitor glucose
4. Gemfibrozil: ↑ Pioglitazone levels—avoid combination
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.