Product Information:

ZOLIGET 15mg/2mg Tablets is a fixed-dose combination of two oral antidiabetic agents:

1. Pioglitazone Hydrochloride 15mg – a thiazolidinedione (TZD) that enhances insulin sensitivity in muscle, fat, and liver by activating PPAR-γ receptors
2. Glimepiride 2mg – a sulfonylurea that stimulates insulin secretion from pancreatic beta cells

This dual-mechanism combination addresses both insulin resistance and impaired insulin secretion, two key pathophysiological defects in type 2 diabetes mellitus.

Uses of (ZOLIGET 15MG/2MG TABLETS):

1. Management of type 2 diabetes mellitus in adults
2. Patients inadequately controlled on pioglitazone or glimepiride monotherapy
3. Those requiring dual therapy targeting both insulin sensitivity and insulin release

Key Benefits of (ZOLIGET 15MG/2MG TABLETS):

1. Dual action improves fasting and postprandial glycemic control
2. Pioglitazone reduces insulin resistance without causing hypoglycemia
3. Glimepiride provides consistent insulin stimulation with once-daily dosing
4. Reduces pill burden and improves adherence

How To Use (ZOLIGET 15MG/2MG TABLETS):

1. Take once daily with breakfast or the first main meal to reduce hypoglycemia risk.
2. Swallow whole with water—do not crush or chew.
3. Continue diet, exercise, and regular blood glucose monitoring.
4. Do not skip meals while on this medication.

When Not to Use (ZOLIGET 15MG/2MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal or hepatic impairment
3. History of bladder cancer (pioglitazone risk)
4. Heart failure (NYHA Class III or IV)
5. Hypersensitivity to pioglitazone, glimepiride, or sulfonylureas

⚠️ Note: Glimepiride can cause hypoglycemia—avoid alcohol and ensure regular meals.

Side Effects of (ZOLIGET 15MG/2MG TABLETS):

Common:

1. Hypoglycemia (dizziness, sweating, tremor, confusion)—especially if meals are skipped
2. Weight gain (from both components)
3. Peripheral edema (from pioglitazone)
4. Headache, nausea

Less common:

1. Bone fractures (pioglitazone—especially in women)
2. Photosensitivity (glimepiride)
3. Mild anemia

Serious (rare but require attention):

1. Severe hypoglycemia (loss of consciousness)—requires emergency glucose
2. Worsening heart failure (shortness of breath, swelling)
3. Bladder cancer (hematuria, urinary urgency—pioglitazone-related)
4. Hepatotoxicity (jaundice, dark urine)
5. Seek immediate help if symptoms of severe hypoglycemia, heart failure, or blood in urine occur.

Dosage: (ZOLIGET 15MG/2MG TABLETS):

1. Adults: 1 tablet once daily with breakfast
2. Maximum daily dose: Pioglitazone 45mg + Glimepiride 8mg
3. Elderly or hepatic/renal impairment: Use with caution; may require lower doses

Who It’s For (ZOLIGET 15MG/2MG TABLETS):

Adults with type 2 diabetes who require combination therapy targeting both insulin resistance and deficient insulin secretion, and who can adhere to regular meal schedules to mitigate hypoglycemia risk.

Warnings & Precautions:

1. Monitor blood glucose regularly, especially during dose changes
2. Avoid alcohol—increases hypoglycemia risk
3. Assess for heart failure symptoms and bladder cancer signs periodically
4. Use caution in elderly patients (higher hypoglycemia risk)
5. Discontinue 48 hours before iodinated contrast procedures (due to metformin-free but glimepiride risk)

Drug Interactions:

1. Beta-blockers: May mask hypoglycemia symptoms
2. NSAIDs, salicylates, sulfonamides: ↑ Hypoglycemia risk
3. Rifampin: ↓ Glimepiride efficacy
4. Gemfibrozil: ↑ Pioglitazone levels
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.