Product Information:

ZOLID PLUS 15/850mg Tablets is a fixed-dose combination of two oral antidiabetic agents:

1. Pioglitazone Hydrochloride 15mg – a thiazolidinedione (TZD) that improves insulin sensitivity in muscle, fat, and liver tissues by activating PPAR-γ receptors
2. Metformin Hydrochloride 850mg – a biguanide that reduces hepatic glucose production and enhances peripheral glucose uptake

This combination is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are inadequately controlled on metformin or pioglitazone monotherapy.

Uses of (ZOLID PLUS 15/850MG TABLETS):

1. Management of type 2 diabetes mellitus in adults
2. Patients not achieving target HbA1c on metformin alone or pioglitazone alone
3. Those requiring dual therapy to address both insulin resistance and hepatic glucose overproduction

Key Benefits of (ZOLID PLUS 15/850MG TABLETS):

1. Dual mechanism targets multiple pathways of hyperglycemia
2. Metformin reduces fasting glucose and weight-neutral effect
3. Pioglitazone improves insulin sensitivity and may preserve beta-cell function
4. Once- or twice-daily dosing for convenience
5. Reduces pill burden compared to separate tablets

How To Use (ZOLID PLUS 15/850MG TABLETS):

1. Take with meals to reduce gastrointestinal side effects.
2. Typical regimen: 1 tablet once or twice daily, as directed by your physician.
3. Swallow whole with water—do not crush or chew.
4. Continue diet, exercise, and regular blood glucose monitoring.

When Not to Use (ZOLID PLUS 15/850MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min)
3. Active liver disease or elevated ALT >2.5× upper limit
4. History of bladder cancer (pioglitazone may increase risk)
5. Heart failure (NYHA Class III or IV)
6. Hypersensitivity to pioglitazone, metformin, or any excipients

⚠️ Temporary discontinuation required: Before iodinated contrast imaging or major surgery.

Side Effects of (ZOLID PLUS 15/850MG TABLETS):

Common:

1. Nausea, diarrhea, abdominal discomfort (mainly from metformin)
2. Weight gain, edema (from pioglitazone)
3. Headache, upper respiratory infection

Less common:

1. Vitamin B12 deficiency (long-term metformin use)
2. Bone fractures (pioglitazone—especially in women)
3. Mild anemia

Serious (rare):

1. Lactic acidosis (symptoms: muscle pain, weakness, slow heartbeat, trouble breathing)—medical emergency
2. Heart failure exacerbation (shortness of breath, rapid weight gain, swelling)
3. Bladder cancer (risk with long-term pioglitazone use >1 year)
4. Hepatotoxicity (jaundice, dark urine, fatigue)
5. Discontinue and seek help if severe symptoms occur.

Dosage: (ZOLID PLUS 15/850MG TABLETS):

1. Adults: Typically 1 tablet once or twice daily
2. Maximum daily dose: Pioglitazone 45mg + Metformin 2000mg
3. Renal function:
4. eGFR ≥45 mL/min: Safe to use
5. eGFR 30–44 mL/min: Avoid initiation; use only if benefits outweigh risks
6. eGFR <30 mL/min: Contraindicated

Who It’s For (ZOLID PLUS 15/850MG TABLETS):

Adults with type 2 diabetes requiring dual therapy beyond metformin monotherapy, particularly those with significant insulin resistance and no contraindications to TZDs.

Warnings & Precautions:

1. Monitor renal function before and during therapy
2. Check liver enzymes before starting and periodically thereafter
3. Assess heart failure symptoms regularly
4. Screen for bladder cancer in patients with hematuria or prior history
5. Discontinue 48 hours before procedures involving iodinated contrast
6. Avoid excessive alcohol intake (↑ lactic acidosis risk)

Drug Interactions:

1. Iodinated contrast agents: Temporarily stop metformin to avoid lactic acidosis
2. Cimetidine, furosemide, nifedipine: May increase metformin levels
3. Gemfibrozil, rifampin: May alter pioglitazone metabolism
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.