Product Information:

ZOLID 30mg Tablets contain Pioglitazone Hydrochloride 30mg, a thiazolidinedione (TZD) class oral antidiabetic agent. It works by activating peroxisome proliferator-activated receptor-gamma (PPAR-γ) in adipose tissue, muscle, and liver, thereby enhancing insulin sensitivity and reducing insulin resistance—a core pathophysiological feature of type 2 diabetes mellitus.

This intermediate-strength formulation is commonly used as a maintenance dose or for patients requiring more robust glycemic control than the 15mg dose provides.

Uses of (ZOLID 30MG TABLETS):

1. Monotherapy or add-on treatment of type 2 diabetes mellitus in adults
2. Patients inadequately controlled on metformin, sulfonylureas, or basal insulin
3. Those with significant insulin resistance and no contraindications to TZDs

Key Benefits of (ZOLID 30MG TABLETS):

1. Significantly improves insulin sensitivity in peripheral and hepatic tissues
2. Reduces both fasting and postprandial hyperglycemia
3. May help preserve beta-cell function over time
4. Weight gain and edema are generally manageable at this dose

How To Use (ZOLID 30MG TABLETS):

1. Take once daily, with or without food, at the same time each day.
2. Swallow whole with water—do not crush or chew.
3. Typical dosing:
4. Maintenance dose: 30mg once daily
5. May be increased to 45mg once daily if HbA1c remains above target after 8–12 weeks
6. Continue diet, exercise, and regular blood glucose monitoring.

When Not to Use (ZOLID 30MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Active liver disease or ALT >2.5× upper limit
3. History of bladder cancer (pioglitazone may increase risk)
4. Heart failure (NYHA Class III or IV)
5. Hypersensitivity to pioglitazone or any excipients

⚠️ Important: Pioglitazone is contraindicated in patients with active or prior bladder cancer.

Side Effects of (ZOLID 30MG TABLETS):

Common:

1. Weight gain (dose-dependent)
2. Peripheral edema (swelling in ankles/legs)
3. Headache, upper respiratory infection

Less common:

1. Bone fractures (especially in postmenopausal women)
2. Mild anemia
3. Elevated liver enzymes

Serious (rare but require monitoring):

1. Worsening heart failure (shortness of breath, rapid weight gain, fatigue)—discontinue immediately
2. Bladder cancer (hematuria, urinary urgency, pelvic pain)—risk increases with duration of use (>1 year)
3. Hepatotoxicity (jaundice, dark urine, right upper quadrant pain)—monitor LFTs periodically
4. Seek medical help if signs of heart failure, blood in urine, or yellowing of skin/eyes occur.

Dosage: (ZOLID 30MG TABLETS):

1. Adults: 30mg once daily
2. Maximum dose: 45mg once daily
3. Elderly or mild hepatic impairment: Use with caution; avoid if severe liver disease
4. Renal impairment: No dose adjustment needed (not primarily renally excreted)

Who It’s For (ZOLID 30MG TABLETS):

Adults with type 2 diabetes who require stronger insulin-sensitizing therapy and have no contraindications to thiazolidinediones, particularly those already tolerating the 15mg dose.

Warnings & Precautions:

1. Monitor liver function tests (LFTs) before starting and annually thereafter
2. Assess for signs of heart failure at every visit
3. Screen for bladder cancer in high-risk patients (e.g., smokers, hematuria)
4. Use caution in postmenopausal women (increased fracture risk)
5. Avoid in patients with diabetic macular edema

Drug Interactions:

1. Gemfibrozil: ↑ Pioglitazone levels—avoid combination
2. Rifampin: ↓ Pioglitazone efficacy—monitor blood glucose
3. Insulin or sulfonylureas: May increase risk of hypoglycemia
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.