Product Information:

ZETRO 250mg Tablets contain Cefpodoxime Proxetil 250mg, a third-generation oral cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Cefpodoxime demonstrates broad-spectrum activity against both Gram-positive bacteria (e.g., Streptococcus pneumoniae, Staphylococcus aureus) and Gram-negative organisms (e.g., Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae).

This strength is commonly used for the treatment of moderate bacterial infections in adults and adolescents.

Uses of (ZETRO 250MG TABLETS):

1. Acute bacterial bronchitis and exacerbations of chronic bronchitis
2. Pharyngitis and tonsillitis caused by Streptococcus pyogenes
3. Acute sinusitis
4. Uncomplicated urinary tract infections (UTIs)
5. Community-acquired pneumonia (mild to moderate)
6. Uncomplicated skin and soft tissue infections
7. Gonorrhea (uncomplicated urethral or cervical—single-dose regimen)

Key Benefits of (ZETRO 250MG TABLETS):

1. Broad-spectrum coverage for common community-acquired pathogens
2. Twice-daily dosing with good tissue penetration
3. Oral convenience for outpatient management
4. Generally well-tolerated with low risk of serious side effects

How To Use (ZETRO 250MG TABLETS):

1. Take with food to enhance absorption (bioavailability increases by ~50%).
2. Swallow whole with water—do not crush or chew.
3. Complete the full prescribed course, even if symptoms improve early.
4. Typical adult dosage:
5. Respiratory/urinary/skin infections: 250mg every 12 hours for 5–10 days
6. Gonorrhea: Single 200mg dose (250mg may be used per local guidelines)

When Not to Use (ZETRO 250MG TABLETS):

Do not use if you have:

1. Hypersensitivity to cefpodoxime, other cephalosporins, or penicillins (cross-reactivity possible)
2. History of severe allergic reaction (anaphylaxis) to beta-lactam antibiotics
3. Severe renal impairment (CrCl <30 mL/min)—requires dose adjustment

⚠️ Note: Ineffective against viral infections (e.g., common cold, flu).

Side Effects of (ZETRO 250MG TABLETS):

Common:

1. Diarrhea, nausea, abdominal pain
2. Headache, dizziness
3. Rash, vaginal candidiasis

Less common:

1. Elevated liver enzymes
2. Eosinophilia, transient leukopenia

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)—persistent watery diarrhea with fever/cramps
2. Anaphylaxis or severe skin reactions (e.g., Stevens-Johnson syndrome)
3. Seizures (in overdose or renal failure)
4. Discontinue and seek emergency care if breathing difficulty, severe rash, or bloody stools occur.

Dosage Adjustments:

1. Renal impairment (CrCl 30–50 mL/min): Reduce dose to 250mg once daily
2. CrCl <30 mL/min: Avoid or use under specialist supervision
3. Elderly: Adjust based on renal function
4. Children: Use suspension formulation; tablets not recommended for young children

Who It’s For (ZETRO 250MG TABLETS):

Adults and adolescents with moderate bacterial infections requiring oral third-generation cephalosporin therapy, particularly for respiratory, urinary, or sexually transmitted infections.

Warnings & Precautions:

1. Use only for bacterial infections—not for viral illnesses
2. Prolonged use may lead to fungal or resistant bacterial overgrowth
3. Monitor for CDAD if diarrhea persists after treatment
4. Cross-reactivity with penicillins possible (~5–10%)

Drug Interactions:

1. Antacids or H2 blockers: May reduce absorption—administer 2 hours apart
2. Probenecid: May increase cefpodoxime levels
3. Oral contraceptives: Antibiotics may reduce efficacy—use backup contraception
4. Anticoagulants: Theoretical risk of increased bleeding (monitor INR)
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.