Product Information:

ZETRO 250mg Capsules contain Cefpodoxime Proxetil 250mg, a third-generation oral cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, resulting in bactericidal activity against a wide range of Gram-positive and Gram-negative pathogens. Cefpodoxime is effective against common community-acquired organisms including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, and Klebsiella pneumoniae.

The capsule formulation offers an alternative to tablets for patients who prefer or better tolerate gelatin-based dosage forms.

Uses of (ZETRO 250MG CAPSULES):

1. Acute bacterial bronchitis and exacerbations of chronic bronchitis
2. Pharyngitis and tonsillitis caused by Streptococcus pyogenes
3. Acute sinusitis
4. Uncomplicated urinary tract infections (UTIs)
5. Community-acquired pneumonia (mild to moderate)
6. Uncomplicated skin and soft tissue infections
7. Uncomplicated gonorrhea (single-dose therapy)

Key Benefits of (ZETRO 250MG CAPSULES):

1. Broad-spectrum coverage for common outpatient infections
2. Twice-daily dosing with reliable absorption
3. Capsule form may be easier to swallow for some patients
4. Generally well-tolerated with low risk of serious adverse effects

How To Use (ZETRO 250MG CAPSULES):

1. Take with food to enhance absorption (bioavailability increases by ~50%).
2. Swallow whole with water—do not open, crush, or chew the capsule.
3. Complete the full prescribed course, even if symptoms improve early.
4. Typical adult dosage:
5. Respiratory, urinary, or skin infections: 250mg every 12 hours for 5–10 days
6. Gonorrhea: Single 200mg dose (250mg may be used per local guidelines)

When Not to Use (ZETRO 250MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to cefpodoxime, other cephalosporins, or penicillins (cross-reactivity possible)
2. History of anaphylaxis to beta-lactam antibiotics
3. Severe renal impairment (CrCl <30 mL/min)—requires dose adjustment

⚠️ Note: Ineffective against viral infections (e.g., common cold, influenza).

Side Effects of (ZETRO 250MG CAPSULES):

Common:

1. Diarrhea, nausea, abdominal discomfort
2. Headache, dizziness
3. Rash, vaginal yeast infection

Less common:

1. Elevated liver enzymes
2. Eosinophilia, transient leukopenia

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)—persistent watery diarrhea with fever/cramps
2. Anaphylaxis or severe skin reactions (e.g., Stevens-Johnson syndrome)
3. Seizures (in overdose or severe renal impairment)
4. Discontinue and seek emergency care if breathing difficulty, widespread rash, or bloody stools occur.

Dosage Adjustments:

1. Renal impairment (CrCl 30–50 mL/min): Reduce to 250mg once daily
2. CrCl <30 mL/min: Avoid or use only under specialist supervision
3. Elderly: Adjust based on renal function
4. Children: Prefer oral suspension; capsules not recommended for young children

Who It’s For (ZETRO 250MG CAPSULES):

Adults and adolescents with moderate bacterial infections who prefer or require a capsule formulation for ease of swallowing, particularly for respiratory, urinary, or sexually transmitted infections.

Warnings & Precautions:

1. Use only for confirmed or suspected bacterial infections
2. Prolonged use may lead to fungal overgrowth or antimicrobial resistance
3. Monitor for CDAD if diarrhea develops during or after treatment
4. Cross-reactivity with penicillins occurs in ~5–10% of allergic individuals

Drug Interactions:

1. Antacids, H2 blockers, or proton pump inhibitors: May reduce absorption—administer 2 hours apart
2. Probenecid: May increase cefpodoxime levels
3. Oral contraceptives: Antibiotics may reduce efficacy—use backup contraception
4. Anticoagulants: Theoretical risk of increased bleeding—monitor INR
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.