Product Information:

ZAVGET Escitalopram 10mg Tablets contain Escitalopram Oxalate 10mg, a selective serotonin reuptake inhibitor (SSRI) and the S-enantiomer of citalopram. It is one of the most widely used antidepressants globally due to its efficacy, favorable tolerability, and once-daily dosing. Escitalopram works by selectively inhibiting the reuptake of serotonin in the central nervous system, enhancing serotonergic neurotransmission to improve mood, anxiety, and emotional regulation.

The 10mg dose is commonly used as a starting or maintenance dose for depression and anxiety disorders in adults.

Uses of (ZAVGET ESCITALOPRAM 10MG):

1. Major Depressive Disorder (MDD) in adults and adolescents (≥12 years)
2. Generalized Anxiety Disorder (GAD)
3. Panic Disorder (with or without agoraphobia)
4. Social Anxiety Disorder (SAD)
5. Obsessive-Compulsive Disorder (OCD)

Key Benefits of (ZAVGET ESCITALOPRAM 10MG):

1. High selectivity for serotonin transporter—fewer off-target side effects
2. Lower risk of drug interactions compared to older antidepressants
3. Once-daily dosing improves adherence
4. Effective for both depression and multiple anxiety disorders
5. Generally well-tolerated with low anticholinergic and cardiovascular effects

How To Use (ZAVGET ESCITALOPRAM 10MG):

1. Take once daily, with or without food (preferably at the same time each day).
2. Swallow whole with water—do not crush or chew.
3. Typical dosing:
4. Adults: Start with 10mg once daily; may increase to 20mg after 1–2 weeks if needed
5. Elderly or hepatically impaired: Max 10mg/day
6. Adolescents (12–17 years): 10mg once daily (max dose)
7. Full therapeutic effect may take 2–4 weeks.
8. Do not stop abruptly—taper gradually to avoid discontinuation syndrome (dizziness, irritability, “brain zaps”).

When Not to Use (ZAVGET ESCITALOPRAM 10MG):

Do not use if you have:

1. Hypersensitivity to escitalopram or citalopram
2. Concurrent use of MAO inhibitors (or within 14 days of discontinuation)
3. Prolonged QT interval or congenital long QT syndrome
4. History of torsades de pointes or significant bradycardia

⚠️ Black Box Warning:

Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults (<25 years) during initial treatment. Monitor closely.

Side Effects of (ZAVGET ESCITALOPRAM 10MG):

Common:

1. Nausea, dry mouth
2. Headache, drowsiness or insomnia
3. Increased sweating, fatigue
4. Sexual dysfunction (e.g., delayed ejaculation, decreased libido)

Less common:

1. Weight changes, tremor
2. Diarrhea or constipation

Serious (rare):

1. Serotonin syndrome (agitation, hallucinations, rapid heart rate)—especially with other serotonergic drugs
2. Hyponatremia (low sodium—more common in elderly)
3. QT prolongation (risk increases with high doses or pre-existing heart conditions)
4. Bleeding risk (with NSAIDs, aspirin, or anticoagulants)
5. Seek emergency help if confusion, muscle rigidity, irregular heartbeat, or severe dizziness occurs.

Dosage: (ZAVGET ESCITALOPRAM 10MG):

1. Adults: 10–20mg once daily
2. Elderly/hepatic impairment: Max 10mg once daily
3. Adolescents (12–17): 10mg once daily
4. Maximum dose: 20mg/day (10mg for special populations)

Who It’s For (ZAVGET ESCITALOPRAM 10MG):

Adults and adolescents (≥12 years) diagnosed with depression, GAD, panic disorder, social anxiety, or OCD, especially those seeking a well-tolerated first-line SSRI.

Warnings & Precautions:

1. Avoid alcohol—may worsen CNS depression
2. Screen for bipolar disorder before starting (may trigger mania)
3. Monitor for worsening depression or suicidal ideation, especially in first 8 weeks
4. Use caution in patients with seizure disorders or history of hyponatremia

Drug Interactions:

1. MAO inhibitors: Risk of serotonin syndrome—contraindicated
2. Other SSRIs, SNRIs, tramadol, triptans: ↑ Serotonin syndrome risk
3. NSAIDs, aspirin, warfarin: ↑ Bleeding risk
4. QT-prolonging drugs (e.g., amiodarone, haloperidol): ↑ Arrhythmia risk
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.