Product Information:

ZAVGET 5mg Tablet contains Vilazodone Hydrochloride 5mg, a serotonin modulator and stimulator (SMS) that acts as a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at 5-HT₁A receptors. This dual mechanism enhances serotonergic activity in the brain, offering antidepressant effects with a potentially favorable side effect profile—particularly lower rates of sexual dysfunction and weight gain compared to traditional SSRIs.

The 5mg strength is not a standard dose for vilazodone in global clinical practice. The approved titration starts at 10mg, then 20mg, and finally 50mg as the maintenance dose. Therefore, ZAVGET 5mg may be intended for specific patient populations (e.g., elderly, hepatically impaired) or represent a local formulation for flexible dosing.

⚠️ Critical Note:

Vilazodone must be taken with food (at least 300 kcal). Absorption is reduced by ~50% if taken on an empty stomach, which can lead to treatment failure.

Uses of (ZAVGET 5MG TABLET):

1. Treatment of Major Depressive Disorder (MDD) in adults
2. Potential use in sensitive patients (e.g., elderly, those with liver impairment, or high risk of side effects) requiring ultra-low initiation
3. Off-label: Anxiety disorders (not officially approved)

Key Benefits of (ZAVGET 5MG TABLET):

1. Dual mechanism may improve mood with faster onset
2. Lower risk of sexual dysfunction and weight gain vs. conventional SSRIs
3. Once-daily dosing supports adherence
4. Non-addictive and non-sedating

How To Use (ZAVGET 5MG TABLET):

1. Take once daily with a meal (minimum 300 kcal).
2. Swallow whole with water—do not crush or chew.
3. If used for initiation in sensitive patients:
4. May start at 5mg once daily for 7 days, then increase to 10mg, 20mg, and finally 50mg over 2–3 weeks
5. Do not stop abruptly—taper gradually to avoid discontinuation syndrome (dizziness, “brain zaps,” irritability).

When Not to Use (ZAVGET 5MG TABLET):

Do not use if you have:

1. Hypersensitivity to vilazodone
2. Concurrent use of MAO inhibitors (or within 14 days of discontinuation)
3. Uncontrolled narrow-angle glaucoma
4. Severe hepatic impairment (use with extreme caution even at 5mg)

⚠️ Black Box Warning:

Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults (<25 years) during early treatment. Monitor closely.

Side Effects of (ZAVGET 5MG TABLET):

Common (usually milder at this low dose):

1. Mild nausea, diarrhea
2. Headache, dizziness
3. Insomnia or fatigue

Less common:

1. Dry mouth, decreased appetite
2. Sexual dysfunction (still lower than other SSRIs)

Serious (rare, even at 5mg):

1. Serotonin syndrome (if combined with other serotonergic drugs)
2. Hyponatremia (low sodium—especially in elderly)
3. Bleeding risk (with NSAIDs, aspirin, or anticoagulants)
4. Seek medical help if confusion, muscle rigidity, or severe GI symptoms occur.

Dosage: (ZAVGET 5MG TABLET):

1. Not a standard dose—typically used only in special cases under physician supervision
2. Maximum dose: 50mg/day (after full titration)
3. Elderly or mild hepatic impairment: May start at 5–10mg; max 20–40mg/day

Who It’s For (ZAVGET 5MG TABLET):

1. Adults with MDD who are highly sensitive to medications
2. Elderly patients or those with mild liver dysfunction requiring cautious initiation
3. Patients experiencing intolerable side effects at 10mg

Warnings & Precautions:

1. Always take with food—critical for absorption
2. Avoid alcohol—may worsen dizziness or CNS effects
3. Screen for bipolar disorder before starting (risk of mania)
4. Monitor for worsening depression or suicidal ideation, especially in first 8 weeks

Drug Interactions:

1. MAO inhibitors: Contraindicated—risk of serotonin syndrome
2. SSRIs, SNRIs, tramadol, triptans: ↑ Serotonin syndrome risk
3. NSAIDs, warfarin: ↑ Bleeding risk
4. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): ↑ Vilazodone levels—reduce dose
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.