Product Information:

XIFAROX Drops 100mg/mL (10mL bottle) is a strawberry-flavored oral suspension containing Cefixime 100mg per mL, a third-generation cephalosporin antibiotic. It is specifically formulated for infants and young children who require precise, weight-based dosing of cefixime for common bacterial infections.

Cefixime works by inhibiting bacterial cell wall synthesis and demonstrates enhanced activity against Gram-negative bacteria, including Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, and Proteus mirabilis, while also covering key Gram-positive pathogens like Streptococcus pneumoniae.

Uses of (XIFAROX DROPS 100MG/ML):

1. Otitis media (middle ear infection)
2. Pharyngitis and tonsillitis (strep throat)
3. Acute bronchitis and sinusitis
4. Uncomplicated urinary tract infections (UTIs) in children
5. Typhoid fever (as an alternative in susceptible cases)

Key Benefits of (XIFAROX DROPS 100MG/ML):

1. Pediatric-friendly liquid formulation with accurate dosing
2. Once-daily administration improves adherence
3. Broad-spectrum coverage for common childhood bacterial infections
4. Stable at room temperature after reconstitution

How To Use (XIFAROX DROPS 100MG/ML):

1. Shake well before each use.
2. Use the provided oral dropper or syringe for accurate measurement.
3. Administer with or without food (food may reduce stomach upset).
4. Complete the full course even if symptoms improve early.

Dosage (based on weight and indication):

1. Children ≥6 months:
2. General infections: 8 mg/kg once daily (max 400mg/day)
3. Otitis media or severe infections: 8 mg/kg once daily or divided into two doses
4. Duration: Typically 5–10 days (10–14 days for typhoid fever)

💡 Example: A 10kg child → 80mg once daily → 0.8 mL once daily.

When Not to Use (XIFAROX DROPS 100MG/ML):

Do not use if the child has:

1. Hypersensitivity to cefixime, other cephalosporins, or penicillins
2. History of severe allergic reaction (anaphylaxis) to beta-lactam antibiotics
3. Severe renal impairment (dose adjustment required)

⚠️ Note: Ineffective against viral infections (e.g., common cold, flu).

Side Effects of (XIFAROX DROPS 100MG/ML):

Common:

1. Diarrhea, loose stools
2. Nausea, vomiting, abdominal pain
3. Rash, diaper rash (in infants)

Less common:

1. Elevated liver enzymes
2. Fungal overgrowth (oral thrush)

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)—persistent watery diarrhea with fever
2. Anaphylaxis or severe skin reactions (e.g., Stevens-Johnson syndrome)
3. Discontinue and seek help if breathing difficulty, widespread rash, or bloody stools occur.

Dosage Adjustments:

1. Renal impairment (CrCl <60 mL/min): Reduce dose by 50%
2. Infants <6 months: Safety not established—use only under specialist supervision

Who It’s For (XIFAROX DROPS 100MG/ML):

1. Infants (≥6 months) and young children requiring antibiotic therapy for common bacterial infections
2. Patients unable to swallow tablets or capsules

Warnings & Precautions:

1. Use only for bacterial infections—not for viral illnesses
2. Prolonged use may lead to fungal or resistant bacterial overgrowth
3. Monitor for CDAD if diarrhea persists after treatment
4. Cross-reactivity with penicillins possible (~5–10%)

Drug Interactions:

1. Probenecid: May increase cefixime levels
2. Oral contraceptives: Antibiotics may reduce efficacy—irrelevant in pediatric use
3. Always inform your doctor about all medications.

Additional Information:

1. Reconstitution: Add boiled and cooled water to the powder as directed; shake well.
2. Storage: Store at room temperature (below 30°C); discard after 14 days.
3. Keep out of reach of children. Available by prescription in Pakistan.