Product Information:

XIFAROX Suspension 250mg/5mL (60mL bottle) is a strawberry-flavored oral suspension containing Cefixime 250mg per 5mL, a third-generation cephalosporin antibiotic. This higher-concentration formulation is suitable for older children and adults who require accurate dosing but cannot swallow tablets or capsules.

Cefixime works by inhibiting bacterial cell wall synthesis, offering broad-spectrum activity against common Gram-positive and Gram-negative pathogens, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, and Proteus mirabilis.

Uses of (XIFAROX 250MG/5ML SUSPENSION):

1. Acute bacterial bronchitis and sinusitis
2. Pharyngitis and tonsillitis caused by Streptococcus pyogenes
3. Otitis media (middle ear infection)
4. Uncomplicated urinary tract infections (UTIs)
5. Typhoid fever (as an alternative in susceptible cases)

Key Benefits of (XIFAROX 250MG/5ML SUSPENSION):

1. Higher concentration allows smaller volume dosing for older children and adults
2. Once-daily administration improves treatment adherence
3. Broad-spectrum coverage for respiratory, urinary, and enteric infections
4. Palatable flavor enhances patient compliance

How To Use (XIFAROX 250MG/5ML SUSPENSION):

1. Shake well before each use.
2. Use the provided measuring cup or oral syringe for accurate dosing.
3. Administer with or without food (food may reduce gastrointestinal upset).
4. Complete the full prescribed course, even if symptoms improve early.

Dosage Guidelines:

1. Adults & adolescents ≥12 years:
2. Standard infections: 250–400mg once daily → 5–8 mL once daily
3. Gonorrhea (uncomplicated): Single 400mg dose → 8 mL as one-time dose
4. Children (6 months–12 years):
5. 8 mg/kg once daily (max 400mg/day)
6. Example: 20kg child → 160mg → 3.2 mL once daily
7. Duration: Typically 5–10 days (10–14 days for typhoid fever)

When Not to Use (XIFAROX 250MG/5ML SUSPENSION):

Do not use if the patient has:

1. Hypersensitivity to cefixime, other cephalosporins, or penicillins
2. History of anaphylaxis to beta-lactam antibiotics
3. Severe renal impairment (CrCl <30 mL/min)—requires dose adjustment

⚠️ Note: Ineffective against viral infections (e.g., common cold, flu).

Side Effects of (XIFAROX 250MG/5ML SUSPENSION):

Common:

1. Diarrhea, loose stools
2. Nausea, abdominal discomfort
3. Rash, headache

Less common:

1. Vaginal or oral candidiasis (yeast overgrowth)
2. Dizziness, elevated liver enzymes

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)—persistent watery diarrhea with fever/cramps
2. Anaphylaxis or severe skin reactions (e.g., Stevens-Johnson syndrome)
3. Discontinue and seek emergency care if breathing difficulty, widespread rash, or bloody stools occur.

Dosage Adjustments:

1. Renal impairment (CrCl 30–60 mL/min): Reduce dose by 50%
2. CrCl <30 mL/min: Avoid or use under specialist supervision
3. Elderly: Adjust based on renal function

Who It’s For (XIFAROX 250MG/5ML SUSPENSION):

1. Older children, adolescents, and adults who cannot swallow tablets
2. Patients requiring precise dosing for moderate bacterial infections
3. Those needing outpatient antibiotic therapy with once-daily convenience

Warnings & Precautions:

1. Use only for confirmed or suspected bacterial infections
2. Prolonged use may lead to fungal or resistant bacterial overgrowth
3. Monitor for CDAD if diarrhea develops during or after treatment
4. Cross-reactivity with penicillins possible (~5–10%)

Drug Interactions:

1. Probenecid: May increase cefixime levels
2. Oral contraceptives: Antibiotics may reduce efficacy—use backup contraception
3. Anticoagulants: Theoretical risk of enhanced effect—monitor INR
4. Always inform your doctor about all medications.

Additional Information:

1. Reconstitution: Add boiled and cooled water to the powder as directed; shake well.
2. Storage: Store at room temperature (below 30°C); discard unused portion after 14 days.
3. Keep out of reach of children. Available by prescription in Pakistan.