Product Information:

XIFAROX Suspension 125mg/5mL (60mL bottle) is a strawberry-flavored oral suspension containing Cefixime 125mg per 5mL, a third-generation cephalosporin antibiotic. It is specifically designed for children and adults who have difficulty swallowing tablets, offering accurate weight-based dosing for common bacterial infections.

Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It has enhanced activity against Gram-negative bacteria (e.g., Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli) and retains efficacy against key Gram-positive pathogens like Streptococcus pneumoniae and Streptococcus pyogenes.

Uses of (XIFAROX 125MG/5ML SUSPENSION):

1. Otitis media (middle ear infection)
2. Pharyngitis and tonsillitis (strep throat)
3. Acute sinusitis and bronchitis
4. Uncomplicated urinary tract infections (UTIs)
5. Typhoid fever (as an alternative in susceptible cases)

Key Benefits of (XIFAROX 125MG/5ML SUSPENSION):

1. Pediatric-friendly formulation with pleasant taste
2. Once-daily dosing improves adherence
3. Broad-spectrum coverage for common community-acquired infections
4. Convenient 60mL bottle with measuring cup/dropper

How To Use (XIFAROX 125MG/5ML SUSPENSION):

1. Shake well before each use.
2. Use the provided measuring cup or oral syringe for accurate dosing.
3. Administer with or without food (food may reduce stomach upset).
4. Complete the full prescribed course, even if symptoms improve early.

Dosage (based on weight and indication):

1. Children ≥6 months:
2. Standard infections: 8 mg/kg once daily
3. Otitis media or severe infections: May be given as 4 mg/kg twice daily
4. Maximum daily dose: 400mg (16 mL)
5. Duration: Typically 5–10 days (10–14 days for typhoid fever)

💡 Example: A 15kg child → 120mg once daily → 4.8 mL once daily.

When Not to Use (XIFAROX 125MG/5ML SUSPENSION):

Do not use if the patient has:

1. Hypersensitivity to cefixime, other cephalosporins, or penicillins
2. History of anaphylaxis to beta-lactam antibiotics
3. Severe renal impairment (dose adjustment required)

⚠️ Note: Ineffective against viral infections (e.g., common cold, flu).

Side Effects of (XIFAROX 125MG/5ML SUSPENSION):

Common:

1. Diarrhea, loose stools
2. Nausea, abdominal pain
3. Rash, diaper rash (in infants)

Less common:

1. Headache, dizziness
2. Oral thrush (fungal overgrowth)

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)—persistent watery diarrhea with fever/cramps
2. Anaphylaxis or severe skin reactions (e.g., Stevens-Johnson syndrome)
3. Discontinue and seek emergency care if breathing difficulty, widespread rash, or bloody stools occur.

Dosage Adjustments:

1. Renal impairment (CrCl <60 mL/min): Reduce dose by 50%
2. Infants <6 months: Safety not established—use only under specialist supervision

Who It’s For (XIFAROX 125MG/5ML SUSPENSION):

1. Children (≥6 months) and adults unable to swallow solid dosage forms
2. Patients requiring precise antibiotic dosing for respiratory, ear, urinary, or enteric infections

Warnings & Precautions:

1. Use only for bacterial infections—not for viral illnesses
2. Prolonged use may lead to fungal or resistant bacterial overgrowth
3. Monitor for CDAD if diarrhea persists during or after treatment
4. Cross-reactivity with penicillins possible (~5–10%)

Drug Interactions:

1. Probenecid: May increase cefixime levels
2. Oral contraceptives: Antibiotics may reduce efficacy—use backup contraception in adolescents/adults
3. Always inform your doctor about all medications.

Additional Information:

1. Reconstitution: Add specified amount of boiled and cooled water to the powder as per label instructions; shake well.
2. Storage: Store at room temperature (below 30°C); discard unused portion after 14 days.
3. Keep out of reach of children. Available by prescription in Pakistan.