Product Information:

XETICAM Oral Solution 100mg/60mL is a strawberry-flavored oral suspension containing Cefuroxime Axetil 100mg per 5mL, a second-generation cephalosporin antibiotic. It is specifically formulated for children and adults who have difficulty swallowing tablets, providing accurate dosing based on body weight.

Cefuroxime axetil works by inhibiting bacterial cell wall synthesis, offering broad-spectrum activity against common Gram-positive and Gram-negative pathogens, including many beta-lactamase-producing strains.

Uses of (XETICAM ORAL SOL 100MG/60ML):

1. Otitis media (middle ear infection)
2. Pharyngitis and tonsillitis (strep throat)
3. Sinusitis (acute bacterial)
4. Bronchitis (acute bacterial exacerbation)
5. Urinary tract infections (UTIs) in children
6. Early Lyme disease (erythema migrans)

Key Benefits of (XETICAM ORAL SOL 100MG/60ML):

1. Pediatric-friendly formulation with pleasant taste
2. Accurate weight-based dosing for optimal efficacy
3. Effective against common childhood bacterial pathogens
4. Resistant to many beta-lactamases (e.g., from H. influenzae, M. catarrhalis)
5. Once- or twice-daily dosing improves adherence

How To Use (XETICAM ORAL SOL 100MG/60ML):

1. Shake well before each use.
2. Use the provided measuring device (oral syringe or cup).
3. Administer with food to enhance absorption and reduce stomach upset.
4. Complete the full course even if symptoms improve early.

Dosage (based on indication and age):

1. Children ≥3 months:
2. Otitis media, sinusitis, pharyngitis: 10–15 mg/kg/dose twice daily (max 250mg per dose)
3. UTI: 10 mg/kg/dose twice daily
4. Lyme disease: 15 mg/kg/dose twice daily (max 500mg/day)
5. Duration: Typically 5–10 days (10–20 days for Lyme disease)

💡 Example: A 15kg child with ear infection → 150–225mg/day → ~7.5–11.25mL/day in two divided doses.

When Not to Use (XETICAM ORAL SOL 100MG/60ML):

Do not use if the patient has:

1. Hypersensitivity to cefuroxime, other cephalosporins, or penicillins
2. History of severe allergic reaction (anaphylaxis) to beta-lactam antibiotics
3. Severe renal impairment (dose adjustment required)

⚠️ Note: Ineffective against viral infections (e.g., common cold, flu).

Side Effects of (XETICAM ORAL SOL 100MG/60ML):

Common:

1. Diarrhea, nausea, vomiting
2. Abdominal pain, diaper rash (in infants)
3. Rash, headache

Less common:

1. Elevated liver enzymes
2. Fungal overgrowth (oral or vaginal thrush)

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)—persistent watery diarrhea with fever
2. Anaphylaxis or severe skin reactions (e.g., Stevens-Johnson syndrome)
3. Discontinue and seek help if breathing difficulty, widespread rash, or bloody stools occur.

Dosage Adjustments:

1. Renal impairment (CrCl <30 mL/min): Reduce dose by 50%
2. Infants <3 months: Safety not established—use only under specialist care

Who It’s For (XETICAM ORAL SOL 100MG/60ML):

1. Infants (≥3 months), children, and adults unable to swallow tablets
2. Patients requiring precise antibiotic dosing for common bacterial infections

Warnings & Precautions:

1. Use only for bacterial infections—not for viral illnesses
2. Prolonged use may lead to fungal or resistant bacterial overgrowth
3. Monitor for CDAD if diarrhea persists after treatment
4. Cross-reactivity with penicillins possible (~5–10%)

Drug Interactions:

1. Probenecid: May increase cefuroxime levels
2. Oral contraceptives: Antibiotics may reduce efficacy—use backup contraception
3. Always inform your doctor about all medications.

Additional Information:

1. Reconstitution: Add specified amount of water to powder as per label; shake well.
2. Storage: Store reconstituted suspension in refrigerator (2–8°C); discard after 10 days.
3. Keep out of reach of children. Available by prescription in Pakistan.