Product Information:

XETICAM 250mg Tablets contain Cefuroxime Axetil 250mg, a second-generation cephalosporin antibiotic. It works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. Cefuroxime axetil is the oral prodrug of cefuroxime, which is active against a broad spectrum of Gram-positive and Gram-negative bacteria.

This formulation is used to treat a variety of mild to moderate bacterial infections in adults and children.

Uses of (XETICAM 250MG TABS):

1. Respiratory tract infections: Acute bronchitis, pharyngitis, tonsillitis, sinusitis
2. Urinary tract infections (UTIs): Cystitis, pyelonephritis (mild to moderate)
3. Skin and soft tissue infections: Cellulitis, impetigo, wound infections
4. Lyme disease (early stage with erythema migrans)
5. Otitis media (in pediatric formulations)

Key Benefits of (XETICAM 250MG TABS):

1. Broad-spectrum coverage against common community-acquired pathogens
2. Resistant to many beta-lactamases produced by Haemophilus influenzae and Moraxella catarrhalis
3. Oral dosing with good bioavailability
4. Generally well-tolerated with low risk of serious side effects

How To Use (XETICAM 2550MG TABS):

1. Take with food to enhance absorption and reduce gastrointestinal upset.
2. Swallow whole with water—do not crush or chew.
3. Complete the full course even if symptoms improve early.
4. Typical adult dosage:
5. Respiratory/urinary/skin infections: 250mg twice daily for 5–10 days
6. Lyme disease: 250mg twice daily for 20 days
7. Dosage may be adjusted based on infection severity and renal function.

When Not to Use (XETICAM 250MG TABS):

Do not use if you have:

1. Hypersensitivity to cefuroxime, other cephalosporins, or penicillins (cross-reactivity possible)
2. History of severe allergic reaction to beta-lactam antibiotics
3. Severe renal impairment (dose adjustment required)

⚠️ Note: Not effective against viral infections (e.g., common cold, flu).

Side Effects of (XETICAM 250MG TABS):

Common:

1. Diarrhea, nausea, vomiting
2. Abdominal pain, headache
3. Rash, vaginitis

Less common:

1. Elevated liver enzymes
2. Dizziness, fatigue

Serious (rare):

1. Clostridioides difficile-associated diarrhea (CDAD)—persistent watery diarrhea with fever
2. Severe allergic reactions (anaphylaxis, Stevens-Johnson syndrome)
3. Hemolytic anemia or seizures (in overdose or renal failure)
4. Discontinue and seek help if severe diarrhea, rash, swelling, or breathing difficulty occurs.

Dosage: (XETICAM 250MG TABS):

1. Adults: 250mg twice daily (may increase to 500mg twice daily for severe infections)
2. Children: Dosed by weight (20–30 mg/kg/day in 2 divided doses)
3. Renal impairment: Reduce dose if CrCl <30 mL/min

Who It’s For (XETICAM 250MG TABS):

Adults and children with confirmed or suspected bacterial infections caused by susceptible organisms, particularly respiratory, urinary, or skin infections.

Warnings & Precautions:

1. Use only for bacterial infections—not for viral illnesses
2. Prolonged use may lead to fungal or resistant bacterial overgrowth
3. Monitor for signs of CDAD (especially if diarrhea persists after treatment)
4. Use caution in patients with history of colitis or renal impairment

Drug Interactions:

1. Probenecid: May increase cefuroxime levels
2. Oral contraceptives: Antibiotics may reduce efficacy—use backup contraception
3. Anticoagulants: Theoretical risk of increased bleeding (monitor INR)
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.