Product Information:

VOXVER 20mg Tablets contain Vortioxetine 20mg, a multimodal antidepressant used for the treatment of Major Depressive Disorder (MDD) in adults. Vortioxetine works through a unique dual mechanism:

1. Serotonin reuptake inhibition (like SSRIs)
2. Modulation of multiple serotonin receptors (5-HT₁A agonist, 5-HT₃, 5-HT₇, and 5-HT₁D antagonists)

This multimodal action enhances neurotransmission of serotonin, dopamine, norepinephrine, and acetylcholine in key brain regions, leading to improved mood and cognitive function—particularly in areas like attention, memory, and executive function.

The 20mg dose is the maximum approved daily dose, typically reserved for patients who do not respond adequately to lower doses.

Uses of (VOXVER 20MG TABS):

1. Major Depressive Disorder (MDD) in adults
2. Particularly beneficial for patients with depression-associated cognitive dysfunction (e.g., poor concentration, memory issues)

Key Benefits of (VOXVER 20MG TABS):

1. Improves both emotional and cognitive symptoms of depression
2. Lower incidence of sexual dysfunction and weight gain compared to traditional SSRIs/SNRIs
3. Once-daily dosing
4. Non-sedating and non-addictive

How To Use (VOXVER 20MG TABS):

1. Take once daily, with or without food, at the same time each day.
2. Swallow whole with water—do not crush or chew.
3. Dose escalation is recommended:
4. Start at 10mg once daily
5. After 1–2 weeks, may increase to 15mg or 20mg based on response and tolerability
6. Full therapeutic effect may take 2–4 weeks.
7. Do not stop abruptly—taper gradually to avoid discontinuation syndrome (dizziness, nausea, irritability).

When Not to Use (VOXVER 20MG TABS):

Do not use if you have:

1. Hypersensitivity to vortioxetine
2. Concurrent use of MAO inhibitors (or within 14 days of discontinuation)
3. Uncontrolled narrow-angle glaucoma

⚠️ Black Box Warning:

Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults (<25 years) during early treatment. Monitor closely.

Side Effects of (VOXVER 20MG TABS):

Common (more frequent at 20mg):

1. Nausea (most common, usually transient)
2. Headache, dizziness
3. Dry mouth, constipation
4. Insomnia or abnormal dreams

Less common:

1. Sexual dysfunction (lower than SSRIs but still possible)
2. Sweating, fatigue
3. Weight changes (usually minimal)

Serious (rare):

1. Serotonin syndrome (agitation, hallucinations, rapid heart rate)—especially with other serotonergic drugs
2. Hyponatremia (low sodium—especially in elderly)
3. Bleeding risk (with NSAIDs, aspirin, or anticoagulants)
4. Seek medical help if confusion, muscle rigidity, severe GI symptoms, or unusual bruising occurs.

Dosage: (VOXVER 20MG TABS):

1. Adults: Start at 10mg once daily; may increase to 15mg or 20mg once daily
2. Maximum dose: 20mg once daily
3. Elderly or hepatically impaired: Max 10mg once daily

Who It’s For (VOXVER 20MG TABS):

Adults with moderate to severe MDD, especially those with prominent cognitive symptoms or intolerance to side effects of conventional antidepressants.

Warnings & Precautions:

1. Avoid alcohol—may worsen CNS effects
2. Screen for bipolar disorder before starting (risk of mania)
3. Monitor for worsening depression or suicidal ideation, especially in first 8 weeks
4. Use caution in patients with seizure disorders or history of hyponatremia

Drug Interactions:

1. MAO inhibitors: Contraindicated—risk of serotonin syndrome
2. SSRIs, SNRIs, tramadol, triptans: ↑ Serotonin syndrome risk
3. NSAIDs, warfarin: ↑ Bleeding risk
4. Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): May increase vortioxetine levels—consider dose reduction
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.