Product Information:

VONOZAN 20mg Tablets contain Vonoprazan Fumarate 20mg, a first-in-class potassium-competitive acid blocker (P-CAB) that provides potent and sustained suppression of gastric acid secretion by reversibly inhibiting the H⁺/K⁺ ATPase (proton pump) in gastric parietal cells. Unlike conventional proton pump inhibitors (PPIs), vonoprazan works rapidly, does not require acid activation, and delivers more consistent acid control—even in patients with CYP2C19 genetic variations that reduce PPI efficacy.

This higher-strength formulation is used for conditions requiring intensified acid suppression, including Helicobacter pylori eradication and severe GERD.

Uses of (VONOZAN 20MG TABLETS):

1. First-line therapy for H. pylori eradication (combined with antibiotics)
2. Treatment of gastric and duodenal ulcers
3. Healing of moderate to severe erosive esophagitis
4. Management of refractory GERD unresponsive to standard PPI therapy
5. Maintenance therapy in high-risk patients

Key Benefits of (VONOZAN 20MG TABLETS):

1. Faster and stronger acid suppression than PPIs (achieves pH >4 for >20 hours/day)
2. Consistent efficacy regardless of CYP2C19 metabolizer status
3. Higher H. pylori eradication rates (up to 90% in clinical studies)
4. Once- or twice-daily dosing depending on indication
5. No need for fasting before dosing—can be taken with or without food

How To Use (VONOZAN 20MG TABLETS):

1. Swallow whole with water—do not crush or chew.
2. For H. pylori eradication:
3. 20mg twice daily + two antibiotics (e.g., amoxicillin + clarithromycin) for 7–14 days
4. For ulcers or erosive esophagitis:
5. 20mg once daily for 4–8 weeks
6. Maintenance GERD:
7. 10–20mg once daily, based on symptom control
8. Can be taken with or without food

When Not to Use (VONOZAN 20MG TABLETS):

Do not use if you have:

1. Hypersensitivity to vonoprazan or any excipients
2. Concomitant use of rilpivirine-containing HIV medications (reduces antiviral efficacy)
3. Severe hepatic impairment (use with caution)

⚠️ Important: Rule out gastric cancer in patients with alarm symptoms (weight loss, dysphagia, GI bleeding) before initiating long-term therapy.

Side Effects of (VONOZAN 20MG TABLETS):

Common:

1. Diarrhea, abdominal discomfort
2. Headache, nausea
3. Elevated liver enzymes (ALT/AST)

Less common:

1. Constipation, flatulence
2. Rash, dizziness

Serious (rare):

1. Hypomagnesemia (with long-term use >1 year)—symptoms: muscle cramps, seizures, arrhythmias
2. Vitamin B12 deficiency (with prolonged use)
3. Acute interstitial nephritis (fever, rash, reduced urine output)
4. Discontinue and seek medical help if jaundice, severe diarrhea, or signs of kidney injury occur.

Dosage: (VONOZAN 20MG TABLETS):

1. H. pylori eradication: 20mg twice daily + antibiotics for 7–14 days
2. Ulcers / Erosive esophagitis: 20mg once daily for 4–8 weeks
3. Maintenance: 10–20mg once daily
4. Maximum dose: 20mg twice daily (only during H. pylori therapy)

Who It’s For (VONOZAN 20MG TABLETS):

1. Adults requiring high-efficacy acid suppression
2. Patients failing PPI therapy due to CYP2C19 metabolism
3. Those undergoing H. pylori eradication needing optimal antibiotic environment
4. Individuals with severe or recurrent GERD/ulcers

Warnings & Precautions:

1. Monitor serum magnesium and vitamin B12 with long-term use (>1 year)
2. Assess bone health in osteoporosis patients—long-term acid suppression may impair calcium absorption
3. Avoid concomitant use with rilpivirine (HIV drug)
4. Do not use for symptomatic relief alone without diagnosis

Drug Interactions:

1. Rilpivirine: ↓ Antiretroviral efficacy—contraindicated
2. Methotrexate: ↑ Toxicity risk—monitor levels
3. Digoxin, tacrolimus, mycophenolate: Altered absorption due to elevated gastric pH
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.