Product Information:

VILGET-M 50mg + 1000mg Tablets is a fixed-dose combination of two oral antidiabetic agents:

1. Vildagliptin 50mg – a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances incretin hormones (GLP-1 and GIP) to stimulate insulin release and suppress glucagon in a glucose-dependent manner
2. Metformin Hydrochloride 1000mg – a biguanide that reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues

This higher-strength combination is used for dual therapy in adults with type 2 diabetes mellitus who require intensified glycemic control beyond lower metformin doses or monotherapy.

Uses of (VILGET-M 50MG + 1000MG TABLETS):

1. Management of type 2 diabetes mellitus in adults
2. Patients inadequately controlled on metformin monotherapy up to 2000mg/day
3. As initial combination therapy in patients with HbA1c ≥9%
4. To reduce pill burden and improve adherence in patients already on separate vildagliptin and metformin

Key Benefits of (VILGET-M 50MG + 1000MG TABLETS):

1. Dual mechanism targets both fasting and postprandial hyperglycemia
2. Low risk of hypoglycemia when used without insulin or sulfonylureas
3. Weight-neutral profile—unlike sulfonylureas, thiazolidinediones, or insulin
4. High metformin dose (1000mg) provides robust glucose-lowering effect
5. Once- or twice-daily dosing for convenience

How To Use (VILGET-M 50MG + 1000MG TABLETS):

1. Take with meals to reduce gastrointestinal side effects.
2. Typical regimen: 1 tablet twice daily (morning and evening with food).
3. May be adjusted based on glycemic response and tolerability.
4. Swallow whole with water—do not crush or chew.
5. Continue diet, exercise, and regular blood glucose monitoring.

When Not to Use (VILGET-M 50MG + 1000MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min)
3. Acute or chronic metabolic acidosis (including lactic acidosis)
4. Hypersensitivity to vildagliptin, metformin, or any excipients
5. History of pancreatitis (use DPP-4 inhibitors cautiously)

⚠️ Temporary discontinuation required: Before iodinated contrast imaging or major surgery.

Side Effects of (VILGET-M 50MG + 1000MG TABLETS):

Common:

1. Nausea, diarrhea, abdominal discomfort (may be more pronounced due to higher metformin dose)
2. Metallic taste, bloating
3. Headache, nasopharyngitis

Less common:

1. Vitamin B12 deficiency (with long-term metformin use)
2. Liver enzyme elevations (monitor LFTs periodically with vildagliptin)

Serious (rare):

1. Lactic acidosis (symptoms: muscle pain, weakness, slow heartbeat, trouble breathing)—medical emergency
2. Acute pancreatitis (persistent severe abdominal pain radiating to back)—discontinue immediately
3. Hepatic dysfunction (jaundice, dark urine, fatigue)—monitor liver function if suspected
4. Seek emergency care if severe symptoms occur.

Dosage: (VILGET-M 50MG + 1000MG TABLETS):

1. Adults: Typically 1 tablet twice daily with meals
2. Maximum daily dose: Vildagliptin 100mg + Metformin 2000mg
3. Renal function guidance:
4. eGFR ≥45 mL/min: Safe to use
5. eGFR 30–44 mL/min: Avoid initiation; use only if benefits outweigh risks
6. eGFR <30 mL/min: Contraindicated

Who It’s For (VILGET-M 50MG + 1000MG TABLETS):

1. Adults with type 2 diabetes requiring high-dose metformin plus DPP-4 inhibition
2. Patients uncontrolled on lower metformin combinations
3. Those seeking simplified dosing with maximum oral therapy before insulin initiation

Warnings & Precautions:

1. Monitor renal function before starting and at least annually
2. Check vitamin B12 levels periodically during long-term therapy
3. Perform liver function tests (LFTs) if clinically indicated (vildagliptin may affect liver enzymes)
4. Discontinue 48 hours before procedures involving iodinated contrast
5. Avoid excessive alcohol intake (increases lactic acidosis risk)

Drug Interactions:

1. Iodinated contrast agents: Temporarily stop metformin to avoid lactic acidosis
2. Cimetidine, furosemide, nifedipine: May increase metformin levels
3. Insulin or sulfonylureas: May increase risk of hypoglycemia
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.