Product Information:

VILGET-M 50/850mg Tablets is a fixed-dose combination of two oral antidiabetic agents:

1. Vildagliptin 50mg – a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances incretin activity to stimulate insulin secretion and suppress glucagon in a glucose-dependent manner
2. Metformin Hydrochloride 850mg – a biguanide that reduces hepatic glucose production and improves insulin sensitivity in muscle and fat tissues

This intermediate-strength combination is commonly used for dual therapy in type 2 diabetes when metformin monotherapy at moderate doses is insufficient.

Uses of (VILGET-M 50/850MG TABLETS):

1. Management of type 2 diabetes mellitus in adults
2. Patients inadequately controlled on metformin 850–1000mg twice daily
3. Initial combination therapy in patients with HbA1c ≥7.5–9%
4. To reduce pill burden and improve adherence compared to separate tablets

Key Benefits of (VILGET-M 50/850MG TABLETS):

1. Dual mechanism targets both fasting and postprandial hyperglycemia
2. Low risk of hypoglycemia when used without insulin or sulfonylureas
3. Weight-neutral profile—unlike insulin, sulfonylureas, or thiazolidinediones
4. Metformin dose (850mg) balances efficacy and gastrointestinal tolerability
5. Once- or twice-daily dosing for convenience

How To Use (VILGET-M 50/850MG TABLETS):

1. Take with meals to minimize gastrointestinal side effects.
2. Typical regimen: 1 tablet twice daily (morning and evening with food).
3. May be adjusted based on blood glucose levels and tolerability.
4. Swallow whole with water—do not crush or chew.
5. Continue diet, exercise, and regular blood glucose monitoring.

When Not to Use (VILGET-M 50/850MG TABLETS):

Do not use if you have:

1. Type 1 diabetes or diabetic ketoacidosis
2. Severe renal impairment (eGFR <30 mL/min)
3. Acute or chronic metabolic acidosis (including lactic acidosis)
4. Hypersensitivity to vildagliptin, metformin, or any excipients
5. History of pancreatitis (use DPP-4 inhibitors cautiously)

⚠️ Temporary discontinuation required: Before iodinated contrast imaging or major surgery.

Side Effects of (VILGET-M 50/850MG TABLETS):

Common:

1. Nausea, diarrhea, abdominal discomfort (usually mild and decreases over time)
2. Metallic taste, bloating
3. Headache, upper respiratory infection

Less common:

1. Vitamin B12 deficiency (with long-term metformin use)
2. Liver enzyme elevations (monitor LFTs periodically with vildagliptin)

Serious (rare):

1. Lactic acidosis (symptoms: unusual muscle pain, drowsiness, slow heartbeat, trouble breathing)—seek emergency care
2. Acute pancreatitis (persistent severe abdominal pain radiating to back)—discontinue immediately
3. Hepatic dysfunction (jaundice, dark urine, fatigue)—monitor liver function if suspected
4. Discontinue and seek help if severe symptoms occur.

Dosage: (VILGET-M 50/850MG TABLETS):

1. Adults: Typically 1 tablet twice daily with meals
2. Maximum daily dose: Vildagliptin 100mg + Metformin 2000mg
3. Renal function guidance:
4. eGFR ≥45 mL/min: Safe to use
5. eGFR 30–44 mL/min: Avoid initiation; use only if benefits outweigh risks
6. eGFR <30 mL/min: Contraindicated

Who It’s For (VILGET-M 50/850MG TABLETS):

1. Adults with type 2 diabetes requiring dual therapy beyond metformin alone
2. Patients transitioning from metformin 850mg monotherapy
3. Those seeking simplified dosing with proven efficacy and tolerability

Warnings & Precautions:

1. Monitor renal function before starting and at least annually
2. Check vitamin B12 levels periodically during long-term therapy
3. Perform liver function tests (LFTs) if clinically indicated (vildagliptin may affect liver enzymes)
4. Discontinue 48 hours before procedures involving iodinated contrast
5. Avoid excessive alcohol intake (increases lactic acidosis risk)

Drug Interactions:

1. Iodinated contrast agents: Temporarily stop metformin to avoid lactic acidosis
2. Cimetidine, furosemide, nifedipine: May increase metformin levels
3. Insulin or sulfonylureas: May increase risk of hypoglycemia
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.