Product Information:

VILGET 50mg Tablets contain Vilazodone Hydrochloride 50mg, a serotonin modulator and stimulator (SMS) that functions as a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at 5-HT₁A receptors. This dual mechanism enhances serotonergic neurotransmission in the brain, providing antidepressant effects with a potentially improved side effect profile—particularly regarding sexual dysfunction and weight gain compared to traditional SSRIs.

The 50mg strength is typically used as the target maintenance dose after initial titration in the treatment of Major Depressive Disorder (MDD).

⚠️ Critical Note:

Vilazodone must be taken with food (at least 300 kcal). Absorption is reduced by ~50% if taken on an empty stomach, which may lead to treatment failure.

Uses of (VILGET 50MG TABLETS):

1. Treatment of Major Depressive Disorder (MDD) in adults
2. Off-label: Generalized anxiety disorder (GAD), though not officially approved for this indication

Key Benefits of (VILGET 50MG TABLETS):

1. Dual action improves mood regulation and may accelerate onset of effect
2. Lower risk of sexual dysfunction and weight gain than many SSRIs
3. Once-daily dosing supports adherence
4. Non-sedating and non-addictive

How To Use (VILGET 50MG TABLETS):

1. Take once daily with a meal (minimum 300 kcal).
2. Swallow whole with water—do not crush or chew.
3. Standard titration schedule:
4. Days 1–7: 10mg once daily with food
5. Days 8–14: 20mg once daily with food
6. From Day 15 onward: 50mg once daily with food (maintenance dose)
7. Do not stop abruptly—taper gradually to avoid discontinuation syndrome (dizziness, irritability, “brain zaps”).

When Not to Use (VILGET 50MG TABLETS):

Do not use if you have:

1. Hypersensitivity to vilazodone
2. Concurrent use of MAO inhibitors (or within 14 days of discontinuation)
3. Uncontrolled narrow-angle glaucoma
4. Severe hepatic impairment

⚠️ Black Box Warning:

Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults (<25 years) during initial treatment. Monitor closely.

Side Effects of (VILGET 50MG TABLETS):

Common (especially during titration):

1. Nausea, diarrhea, vomiting
2. Headache, dizziness
3. Insomnia, abnormal dreams

Less common:

1. Sexual dysfunction (lower risk than other SSRIs)
2. Weight changes (usually minimal)
3. Dry mouth, fatigue

Serious (rare):

1. Serotonin syndrome (agitation, hallucinations, rapid heart rate, high fever)—especially with other serotonergic drugs
2. Hyponatremia (low sodium—more common in elderly)
3. Bleeding risk (with NSAIDs, aspirin, or anticoagulants)
4. Discontinue and seek help if severe GI symptoms, confusion, or muscle rigidity occur.

Dosage: (VILGET 50MG TABLETS):

1. Maintenance dose: 50mg once daily with food
2. Starting dose: Always begin at 10mg and titrate over 2 weeks
3. Maximum dose: 50mg/day
4. Elderly or mild hepatic impairment: Max 20–40mg/day; use with caution

Who It’s For (VILGET 50MG TABLETS):

Adults diagnosed with major depressive disorder who have completed the standard titration protocol and require the full therapeutic dose for sustained symptom control.

Warnings & Precautions:

1. Always take with food—efficacy depends on it
2. Avoid alcohol—may worsen CNS side effects
3. Screen for bipolar disorder before starting (may trigger mania)
4. Monitor for worsening depression or suicidal ideation, especially in first 8 weeks

Drug Interactions:

1. MAO inhibitors: Risk of serotonin syndrome—contraindicated
2. Other serotonergic drugs (SSRIs, SNRIs, triptans, tramadol): ↑ Serotonin syndrome risk
3. NSAIDs, aspirin, warfarin: ↑ Bleeding risk
4. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): ↑ Vilazodone levels—reduce dose
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.