Product Information:

TREVIA 100mg Tablets contain Tramadol Hydrochloride 100mg, a centrally acting synthetic opioid analgesic that provides pain relief through dual mechanisms:

1. Weak mu-opioid receptor agonism
2. Inhibition of serotonin and norepinephrine reuptake

This strength is used for the management of moderate to moderately severe acute or chronic pain in adults when lower doses are insufficient.

⚠️ Important Safety Note:

Tramadol is a Schedule H1 controlled substance in Pakistan due to its potential for dependence, abuse, seizures, and serotonin syndrome. It must be used at the lowest effective dose for the shortest duration necessary.

Uses of (TREVIA 100MG TABLETS):

1. Relief of moderate to severe acute pain (e.g., post-surgical, dental, trauma-related)
2. Management of chronic non-cancer pain (e.g., osteoarthritis, neuropathic pain, low back pain)
3. Alternative to stronger opioids when a lower risk of respiratory depression is desired

Key Benefits of (TREVIA 100MG TABLETS):

1. Effective analgesia with less respiratory depression than morphine
2. Dual mechanism enhances pain control, especially in mixed or neuropathic pain
3. Oral formulation with predictable absorption
4. Lower abuse liability than classic opioids (though still significant)

How To Use (TREVIA 100MG TABLETS):

1. Take every 4–6 hours as needed for pain, with or without food.
2. Swallow whole with water—do not crush, chew, or split.
3. Maximum daily dose:
4. Adults with normal liver/kidney function: 400mg/day (i.e., 4 tablets of 100mg)
5. Elderly or hepatic/renal impairment: 300mg/day (e.g., 100mg every 8 hours)
6. Do not exceed recommended doses or frequency.

When Not to Use (TREVIA 100MG TABLETS):

Do not use if you have:

1. Hypersensitivity to tramadol or other opioids
2. Acute intoxication with alcohol, benzodiazepines, or other CNS depressants
3. Uncontrolled epilepsy or history of seizures
4. Concurrent use of MAO inhibitors (or within 14 days)
5. Severe respiratory depression or acute asthma attack

🚫 Not approved for children <12 years; avoid in adolescents <18 with obesity, obstructive sleep apnea, or compromised respiration.

Side Effects of (TREVIA 100MG TABLETS):

Common:

1. Nausea, dizziness, headache
2. Constipation, dry mouth
3. Drowsiness, sweating

Less common:

1. Vomiting, abdominal discomfort
2. Fatigue, itching, mood changes

Serious (require immediate attention):

1. Seizures (risk increases with high doses, epilepsy, or drug interactions)
2. Serotonin syndrome (agitation, confusion, rapid heart rate, high fever)—especially with SSRIs, SNRIs, or triptans
3. Respiratory depression (slow/shallow breathing—more likely with overdose or combined CNS depressants)
4. Physical dependence and withdrawal (anxiety, insomnia, tremors on abrupt discontinuation)
5. Seek emergency care if muscle rigidity, hallucinations, or breathing difficulties occur.

Dosage: (TREVIA 100MG TABLETS):

1. Adults: 50–100mg every 4–6 hours as needed
2. Starting dose: Often 50mg; 100mg may be used in opioid-tolerant patients
3. Maximum single dose: 100mg
4. Maximum daily dose: 400mg (300mg in elderly or impaired)

Who It’s For (TREVIA 100MG TABLETS):

Adults with moderate to severe pain unresponsive to non-opioid analgesics, requiring short- or long-term opioid therapy under medical supervision.

Warnings & Precautions:

1. Avoid alcohol, sedatives, or benzodiazepines—↑ risk of fatal respiratory depression
2. Use extreme caution in patients with seizure disorders, head injury, or substance use history
3. Taper gradually after prolonged use to prevent withdrawal
4. Monitor for signs of misuse, addiction, or mood changes

Drug Interactions:

1. SSRIs, SNRIs, MAOIs, triptans: ↑ Risk of serotonin syndrome
2. CNS depressants (alcohol, benzodiazepines): ↑ Sedation and breathing suppression
3. Carbamazepine: May reduce tramadol efficacy
4. Quinidine: May increase tramadol levels
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep in a secure, locked location away from children and unauthorized persons. Do not use after the expiration date. Available by prescription only in Pakistan (Schedule H1).