Product Information:

TIRZEE 5mg Pen contains Tirzepatide 5mg, a once-weekly dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. It is used for the treatment of type 2 diabetes mellitus and chronic weight management in adults. Tirzepatide enhances insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety through dual incretin receptor activation.

The 5mg dose is the second step in the titration regimen, following the initial 2.5mg dose, and is often used as a therapeutic maintenance dose for some patients.

✅ Note: This aligns with globally approved products like Mounjaro® (for diabetes) and Zepbound® (for obesity), where 5mg is a standard intermediate dose.

Uses of (TIRZEE 5MG PEN):

1. Type 2 diabetes mellitus – as part of ongoing glycemic management
2. Chronic weight management – for sustained appetite suppression and fat loss
3. May reduce cardiovascular risk in high-risk patients (based on ongoing trials)

Key Benefits of (TIRZEE 5MG PEN):

1. Once-weekly subcutaneous injection – improves adherence
2. Dual hormone action provides superior HbA1c reduction vs. GLP-1 agonists alone
3. Promotes clinically meaningful weight loss (average 10–15% at higher doses; ~5–8% at 5mg)
4. Low risk of hypoglycemia when not combined with insulin or sulfonylureas
5. Improves cardiometabolic markers (blood pressure, lipids)

How To Use (TIRZEE 5MG PEN):

1. Inject once weekly, on the same day each week, with or without meals.
2. Administer subcutaneously in the abdomen, thigh, or upper arm.
3. Do not inject intravenously or intramuscularly.
4. Dose escalation protocol:
5. Weeks 1–4: 2.5mg once weekly
6. Weeks 5–8: 5mg once weekly
7. May escalate further to 7.5mg, 10mg, 12.5mg, or 15mg based on response and tolerability
8. If a dose is missed, administer within 4 days; if >4 days, skip and resume on the next scheduled day.

When Not to Use (TIRZEE 5MG PEN):

Do not use if you have:

1. Personal or family history of medullary thyroid carcinoma (MTC)
2. Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
3. Hypersensitivity to tirzepatide or any excipients
4. Type 1 diabetes or diabetic ketoacidosis

⚠️ Black Box Warning:

Tirzepatide causes thyroid C-cell tumors in rodents. It is contraindicated in patients with MTC risk.

Side Effects of (TIRZEE 5MG PEN):

Common (more noticeable than at 2.5mg, but usually transient):

1. Nausea, vomiting, diarrhea, constipation
2. Decreased appetite, abdominal pain
3. Fatigue, dizziness
4. Injection site reactions (redness, itching)

Less common:

1. Elevated amylase/lipase levels
2. Gallbladder-related symptoms

Serious (rare but require monitoring):

1. Acute pancreatitis (persistent severe upper abdominal pain)—discontinue immediately
2. Gallbladder disease (gallstones, cholecystitis)
3. Acute kidney injury (from dehydration due to GI losses)
4. Worsening diabetic retinopathy (in patients with pre-existing disease)
5. Seek emergency care if severe abdominal pain, vision changes, or persistent vomiting occurs.

Dosage: (TIRZEE 5MG PEN):

1. Intermediate maintenance dose: 5mg once weekly
2. Only initiate after completing ≥4 weeks on 2.5mg
3. Maximum dose: 15mg once weekly

Who It’s For (TIRZEE 5MG PEN):

Adults with type 2 diabetes or obesity who have tolerated the 2.5mg dose and require enhanced glycemic control or weight reduction, and who can adhere to weekly injections.

Warnings & Precautions:

1. Maintain adequate fluid intake to prevent dehydration and renal injury
2. Monitor for signs of pancreatitis or gallbladder disease
3. Use caution in patients with diabetic retinopathy or history of eating disorders
4. Educate on proper pen handling and injection technique

Drug Interactions:

1. Insulin or sulfonylureas: ↑ Risk of hypoglycemia—monitor blood glucose
2. Oral medications: May delay absorption due to slowed gastric emptying—take ≥1 hour before or 4+ hours after tirzepatide
3. Always inform your doctor about all medications.

Additional Information:

1. Store unused pens refrigerated (2–8°C); after first use, store at room temperature (<30°C) for up to 28 days.
2. Do not freeze. Protect from light.
3. Keep out of reach of children. Available by prescription in Pakistan.