Product Information:

TASMI AM 5+80mg Tablets is a fixed-dose combination antihypertensive containing:

1. Amlodipine Besylate 5mg – a calcium channel blocker that relaxes blood vessels by inhibiting calcium influx into vascular smooth muscle
2. Telmisartan 80mg – an angiotensin II receptor blocker (ARB) that blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II

This combination is used for the treatment of essential hypertension in adults who require dual therapy for adequate blood pressure control. The lower dose of amlodipine helps minimize side effects like edema, while the higher dose of telmisartan provides robust RAAS blockade.

⚠️ Note: Despite the brand name "TASMI" (which may suggest tamsulosin), this product does not contain tamsulosin. It is exclusively a combination of amlodipine + telmisartan for high blood pressure.

Uses of (TASMI AM 5+80MG TABLETS):

1. Management of moderate to severe essential hypertension
2. Patients not controlled on monotherapy with either amlodipine or telmisartan
3. Hypertension in patients with type 2 diabetes and proteinuria (telmisartan offers renal protection)
4. Cardiovascular risk reduction in high-risk individuals (e.g., with left ventricular hypertrophy)

Key Benefits of (TASMI AM 5+80MG TABLETS):

1. Dual mechanism: vasodilation + RAAS inhibition for enhanced BP control
2. Lower amlodipine dose (5mg) reduces risk of peripheral edema
3. Higher telmisartan dose (80mg) maximizes antihypertensive and organ-protective effects
4. Once-daily dosing improves adherence

How To Use (TASMI AM 5+80MG TABLETS):

1. Take one tablet once daily, with or without food, at the same time each day.
2. Swallow whole with water—do not crush or chew.
3. Continue therapy even if you feel well—hypertension is often asymptomatic.
4. Full effect may take 2–4 weeks.

When Not to Use (TASMI AM 5+80MG TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, telmisartan, or any excipients
2. Pregnancy (especially 2nd/3rd trimester—can cause fetal injury or death)
3. Severe hepatic impairment or biliary obstructive disorders
4. Concomitant use of aliskiren in diabetic or renally impaired patients

Side Effects of (TASMI AM 5+80MG TABLETS):

Common:

1. Mild peripheral edema (less than with 10mg amlodipine)
2. Dizziness, headache
3. Fatigue, flushing
4. Diarrhea, back pain

Less common:

1. Hyperkalemia (due to telmisartan)
2. Gingival hyperplasia (gum overgrowth—rare at 5mg amlodipine)

Serious (rare):

1. Symptomatic hypotension (especially in volume-depleted patients)
2. Acute kidney injury
3. Angioedema (swelling of face/lips/throat—seek emergency care)
4. Discontinue and seek help if breathing difficulty, severe dizziness, or facial swelling occurs.

Dosage: (TASMI AM 5+80MG TABLETS):

1. Adults: One tablet (amlodipine 5mg + telmisartan 80mg) once daily
2. Elderly or mild hepatic impairment: Generally safe; monitor BP
3. Severe hepatic impairment: Avoid
4. Renal impairment: Safe, but avoid with aliskiren in diabetes

Who It’s For (TASMI AM 5+80MG TABLETS):

Adults with uncontrolled hypertension who:

1. Experience edema with higher amlodipine doses
2. Require maximal RAAS blockade (e.g., diabetics with kidney involvement)
3. Need simplified dual-drug therapy

Warnings & Precautions:

1. Avoid during pregnancy—use effective contraception
2. Monitor serum potassium, creatinine, and blood pressure periodically
3. Use caution in elderly or dehydrated patients
4. Discontinue 24–48 hours before major surgery

Drug Interactions:

1. Potassium-sparing diuretics, potassium supplements: ↑ Risk of hyperkalemia
2. NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and impair kidney function
3. Simvastatin: Amlodipine may ↑ levels—limit simvastatin to 20mg/day
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.