Product Information:

TASMI AM 10+80mg Tablets is a fixed-dose combination containing:

1. Amlodipine Besylate 10mg – a calcium channel blocker that relaxes blood vessels
2. Telmisartan 80mg – an angiotensin II receptor blocker (ARB) that blocks the effects of a vasoconstrictive hormone

This combination is used for the treatment of hypertension (high blood pressure) when monotherapy with either agent is insufficient. The dual mechanism provides enhanced blood pressure control and may offer cardiovascular and renal protection, especially in high-risk patients.

⚠️ Note: Despite the brand name "TASMI" (which may suggest tamsulosin), this product does not contain tamsulosin. It is a combination of amlodipine + telmisartan—commonly used for hypertension.

Uses of (TASMI AM 10+80MG TABLETS):

1. Management of essential hypertension in adults
2. Patients not adequately controlled on amlodipine or telmisartan monotherapy
3. Hypertension in patients with type 2 diabetes and proteinuria (telmisartan offers renal protection)
4. Reduction of cardiovascular risk in high-risk patients (e.g., with left ventricular hypertrophy)

Key Benefits of (TASMI AM 10+80MG TABLETS):

1. Dual antihypertensive action: vasodilation + RAAS blockade
2. Once-daily dosing improves adherence
3. Telmisartan may reduce risk of stroke and slow diabetic kidney disease progression
4. Amlodipine counters telmisartan-induced edema and vice versa

How To Use (TASMI AM 10+80MG TABLETS):

1. Take one tablet once daily, with or without food, at the same time each day.
2. Swallow whole with water—do not crush or chew.
3. Continue therapy even if you feel well—hypertension often has no symptoms.
4. May take 2–4 weeks for full blood pressure effect.

When Not to Use (TASMI AM 10+80MG TABLETS):

Do not use if you have:

1. Hypersensitivity to amlodipine, telmisartan, or any excipients
2. Pregnancy (especially 2nd/3rd trimester—can cause fetal injury or death)
3. Severe hepatic impairment or biliary obstructive disorders
4. Concomitant use of aliskiren in diabetes or renal impairment

Side Effects of (TASMI AM 10+80MG TABLETS):

Common:

1. Peripheral edema (ankle swelling—due to amlodipine)
2. Dizziness, headache
3. Fatigue, flushing
4. Back pain, diarrhea

Less common:

1. Hyperkalemia (high potassium—due to telmisartan)
2. Gingival hyperplasia (gum overgrowth—amlodipine-related)

Serious (rare):

1. Hypotension (especially in volume-depleted patients)
2. Acute kidney injury (in susceptible individuals)
3. Angioedema (swelling of face/lips/throat—seek emergency care)
4. Discontinue and seek help if severe dizziness, breathing difficulty, or swelling occurs.

Dosage: (TASMI AM 10+80MG TABLETS):

1. Adults: One tablet (amlodipine 10mg + telmisartan 80mg) once daily
2. Elderly or mild hepatic impairment: Generally safe; monitor BP
3. Severe hepatic impairment: Avoid
4. Renal impairment: Safe, but avoid with aliskiren in diabetes

Who It’s For (TASMI AM 10+80MG TABLETS):

Adults with moderate to severe hypertension requiring dual therapy, especially those with:

1. Inadequate response to single-agent therapy
2. Type 2 diabetes with albuminuria
3. High cardiovascular risk

Warnings & Precautions:

1. Avoid during pregnancy—use effective contraception
2. Monitor serum potassium and creatinine periodically
3. Use caution in elderly or volume-depleted patients (risk of hypotension)
4. Discontinue 24–48 hours before surgery

Drug Interactions:

1. Potassium supplements, spironolactone: ↑ Risk of hyperkalemia
2. NSAIDs (e.g., ibuprofen): May reduce antihypertensive effect and impair kidney function
3. Simvastatin: Amlodipine may ↑ simvastatin levels—limit simvastatin to 20mg/day
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.