Product Information:

TAMSOLIN 0.4mg Capsules contain Tamsulosin Hydrochloride 0.4mg, a selective alpha-1A adrenergic receptor antagonist used to treat the signs and symptoms of benign prostatic hyperplasia (BPH) in adult men. By blocking alpha-1A receptors in the prostate and bladder neck, tamsulosin relaxes smooth muscle, improving urine flow and reducing urinary obstruction.

This formulation offers once-daily dosing with high uroselectivity—minimizing effects on blood pressure compared to non-selective alpha-blockers.

Uses of (TAMSOLIN 0.4MG CAPSULES):

1. Relief of lower urinary tract symptoms (LUTS) due to BPH, including:
2. Weak or interrupted urine stream
3. Hesitancy (difficulty starting urination)
4. Sensation of incomplete bladder emptying
5. Frequent or urgent urination
6. Nocturia (waking at night to urinate)

Key Benefits of (TAMSOLIN 0.4MG CAPSULES):

1. Rapid improvement in urine flow (within days)
2. High selectivity for prostate/bladder alpha-1A receptors—less effect on vascular alpha-1B receptors
3. Once-daily dosing for consistent symptom control
4. Lower risk of orthostatic hypotension than older alpha-blockers (e.g., terazosin, doxazosin)

How To Use (TAMSOLIN 0.4MG CAPSULES):

1. Take one capsule (0.4mg) once daily, approximately 30 minutes after the same meal each day (to reduce side effects and stabilize absorption).
2. Swallow whole with water—do not crush, chew, or open the capsule.
3. Take at the same time daily for best results.
4. Continue therapy as prescribed—even if symptoms improve.

When Not to Use (TAMSOLIN 0.4MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to tamsulosin or any excipients
2. Severe hepatic impairment
3. Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole) or moderate CYP3A4 + strong CYP2D6 inhibitors together
4. Orthostatic hypotension or severe postural dizziness

⚠️ Note: TAMSOLIN is for men only. Women (especially pregnant) should avoid handling crushed or broken capsules due to potential fetal harm.

Side Effects of (TAMSOLIN 0.4MG CAPSULES):

Common:

1. Retrograde ejaculation (dry orgasm)—most common (~10–20%), harmless but may affect fertility
2. Dizziness, headache
3. Nasal congestion, rhinitis
4. Abnormal ejaculation

Less common:

1. Orthostatic hypotension (less frequent than with non-selective alpha-blockers)
2. Palpitations, fatigue

Serious (rare):

1. Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery—inform your ophthalmologist before any eye procedure
2. Priapism (prolonged erection—seek emergency care)
3. Discontinue and seek help if vision changes or prolonged erection (>4 hours) occurs.

Dosage: (TAMSOLIN 0.4MG CAPSULES):

1. Adults: 0.4mg once daily after a meal
2. Elderly: Generally well-tolerated; no routine dose adjustment
3. Renal or mild hepatic impairment: No adjustment needed
4. Severe hepatic impairment: Avoid

Who It’s For (TAMSOLIN 0.4MG CAPSULES):

Adult men diagnosed with mild to moderate BPH seeking relief from urinary symptoms without significant blood pressure effects.

Warnings & Precautions:

1. Inform all surgeons—especially ophthalmologists—about tamsulosin use due to IFIS risk
2. Avoid driving or operating machinery until response is known (dizziness possible)
3. Use caution with other antihypertensives—may enhance blood pressure-lowering effects
4. Not indicated for hypertension treatment

Drug Interactions:

1. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): May ↑ tamsulosin levels—use with caution
2. Other alpha-blockers or antihypertensives: ↑ Risk of hypotension
3. PDE5 inhibitors (sildenafil, tadalafil): May cause additive blood pressure lowering
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of women and children. Do not use after the expiration date. Available by prescription in Pakistan.