Product Information:

SOLIFEN 5mg Tablets contain Solifenacin Succinate 5mg, a competitive muscarinic receptor antagonist (anticholinergic) that selectively acts on the bladder to inhibit involuntary contractions of the detrusor muscle. It is used as first-line pharmacological therapy for overactive bladder (OAB), helping to reduce urinary urgency, frequency, and urge incontinence.

This standard starting dose offers effective symptom control with a favorable safety profile, especially in elderly or sensitive patients.

Uses of (SOLIFEN 5MG TABLETS):

1. Treatment of overactive bladder (OAB) characterized by:
2. Sudden, strong need to urinate (urgency)
3. Urge urinary incontinence (leakage following urgency)
4. Frequent urination (daytime and nighttime)
5. May be used off-label in neurogenic bladder under specialist supervision

Key Benefits of (SOLIFEN 5MG TABLETS):

1. Reduces OAB symptoms by 50–70% within weeks
2. Improves sleep quality by decreasing nocturia (nighttime urination)
3. Once-daily dosing for consistent 24-hour control
4. Bladder-selective action—lower risk of systemic anticholinergic side effects

How To Use (SOLIFEN 5MG TABLETS):

1. Take one tablet (5mg) once daily with water, with or without food.
2. Swallow whole—do not crush or chew.
3. Preferably taken in the evening to maximize effect on nocturia.
4. Full benefits may take 2–8 weeks—continue as prescribed even if improvement is gradual.

When Not to Use (SOLIFEN 5MG TABLETS):

Do not use if you have:

1. Urinary retention
2. Gastric retention (e.g., severe gastroparesis)
3. Uncontrolled narrow-angle glaucoma
4. Hypersensitivity to solifenacin or any excipients
5. Severe hepatic impairment or moderate impairment with risk factors (e.g., QT prolongation)

⚠️ Caution: Use with extreme care in elderly patients with dementia—anticholinergics may worsen cognition.

Side Effects of (SOLIFEN 5MG TABLETS):

Common:

1. Dry mouth (most frequent)
2. Constipation
3. Blurred vision
4. Dizziness or headache

Less common:

1. Dry eyes, dry skin
2. Urinary tract infection
3. Mild somnolence

Serious (rare):

1. Acute urinary retention (especially in men with enlarged prostate)
2. Severe constipation or paralytic ileus
3. Heat exhaustion (due to reduced sweating in hot environments)
4. Discontinue and seek medical help if inability to urinate, severe abdominal pain, or confusion occurs.

Dosage: (SOLIFEN 5MG TABLETS):

1. Adults (standard starting dose): 5mg once daily
2. Elderly or mild renal/hepatic impairment: 5mg once daily (safe starting dose)
3. Severe renal (CrCl <30 mL/min) or hepatic impairment: Max 5mg/day—do not escalate
4. Maintenance: May increase to 10mg after 4–8 weeks if needed and tolerated

Who It’s For (SOLIFEN 5MG TABLETS):

Adults (including elderly) with newly diagnosed or mild-to-moderate overactive bladder, particularly those at higher risk of side effects from stronger anticholinergics.

Warnings & Precautions:

1. Avoid driving or operating machinery until you know how it affects you
2. Stay well-hydrated and avoid excessive heat exposure (reduced sweating)
3. Use caution in patients with GI motility disorders, myasthenia gravis, or autonomic neuropathy
4. Monitor cognitive function in elderly patients during long-term use

Drug Interactions:

1. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): May increase solifenacin levels—dose adjustment may be needed
2. Other anticholinergics (e.g., diphenhydramine, amitriptyline): Additive side effects (dry mouth, constipation, confusion)
3. QT-prolonging drugs: Theoretical risk—use cautiously in susceptible individuals
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.