Product Information:

SOLIFEN 1 0mg Tablets contain Solifenacin Succinate 10mg, a competitive muscarinic receptor antagonist (anticholinergic) that selectively targets the bladder to reduce involuntary contractions of the detrusor muscle. It is used to treat symptoms of overactive bladder (OAB), including urgency, frequency, and urge incontinence.

This higher-strength formulation is typically reserved for patients who do not achieve adequate symptom control with the 5mg dose.

Uses of (SOLIFEN 10MG TABLETS):

1. Treatment of overactive bladder (OAB) with symptoms of:
2. Urinary urgency
3. Urge urinary incontinence
4. Increased urinary frequency
5. Management of neurogenic detrusor overactivity (off-label, under specialist care)

Key Benefits of (SOLIFEN 10MG TABLETS):

1. Reduces episodes of urgency and incontinence by up to 70%
2. Improves quality of life and sleep (by reducing nocturia)
3. Once-daily dosing for consistent 24-hour control
4. Bladder-selective action—lower risk of systemic anticholinergic effects than older agents

How To Use (SOLIFEN 10MG TABLETS):

1. Take one tablet (10mg) once daily with water, with or without food.
2. Swallow whole—do not crush or chew.
3. Take at the same time each day (evening preferred to reduce nocturia).
4. May take 2–8 weeks for full effect—continue as prescribed.

When Not to Use (SOLIFEN 10MG TABLETS):

Do not use if you have:

1. Urinary retention
2. Gastric retention (e.g., severe gastroparesis)
3. Uncontrolled narrow-angle glaucoma
4. Hypersensitivity to solifenacin or any excipients
5. Severe hepatic impairment or moderate hepatic impairment with QT prolongation risk

⚠️ Caution: Avoid in elderly patients with dementia—anticholinergics may worsen cognitive function.

Side Effects of (SOLIFEN 10MG TABLETS):

Common:

1. Dry mouth (most common)
2. Constipation
3. Blurred vision
4. Dizziness, headache

Less common:

1. Urinary tract infection
2. Dry eyes, dry skin
3. Somnolence

Serious (rare):

1. Urinary retention (especially in men with BPH)
2. Severe constipation or ileus
3. QT prolongation (in overdose or high-risk patients)
4. Heat exhaustion (reduced sweating in hot environments)
5. Discontinue and seek help if inability to urinate, severe abdominal pain, or confusion occurs.

Dosage: (SOLIFEN 10MG TABLETS):

1. Adults: 5mg once daily (starting dose); may increase to 10mg once daily after 4–8 weeks if needed
2. Elderly or mild renal/hepatic impairment: Start at 5mg; 10mg only if well-tolerated
3. Severe renal (CrCl <30 mL/min) or hepatic impairment: Max 5mg/day
4. Maximum dose: 10mg once daily

Who It’s For (SOLIFEN 10MG TABLETS):

Adults with moderate to severe overactive bladder symptoms who require intensified therapy after inadequate response to the 5mg dose.

Warnings & Precautions:

1. Avoid driving or operating machinery until response is known (dizziness possible)
2. Stay hydrated and avoid overheating (reduced sweating)
3. Use caution in patients with GI obstructive disorders, myasthenia gravis, or autonomic neuropathy
4. Monitor for cognitive changes in elderly patients

Drug Interactions:

1. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): ↑ Solifenacin levels—limit dose to 5mg/day
2. Other anticholinergics (e.g., diphenhydramine, tricyclic antidepressants): ↑ Side effects (dry mouth, constipation, confusion)
3. QT-prolonging drugs: Theoretical risk—use cautiously
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.