Product Information:

SIVAB 7.5mg Tablets contain Vilazodone Hydrochloride 7.5mg, a serotonin modulator and stimulator (SMS) that functions as a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at 5-HT₁A receptors. This dual mechanism enhances serotonergic neurotransmission, providing antidepressant efficacy with a potentially improved tolerability profile—particularly regarding sexual dysfunction and weight gain compared to traditional SSRIs.

The 7.5mg strength is typically used as an intermediate titration dose during the initiation phase of treatment for Major Depressive Disorder (MDD).

⚠️ Critical Note:

Vilazodone must be taken with food (at least 300 kcal). Absorption is reduced by ~50% if taken on an empty stomach, which may lead to treatment failure.

Uses of (SIVAB 7.5MG TABLETS):

1. Treatment of Major Depressive Disorder (MDD) in adults
2. May be used off-label for anxiety disorders (e.g., generalized anxiety), though not officially approved

Key Benefits of (SIVAB 7.5MG TABLETS):

1. Dual action improves mood regulation and may accelerate onset of effect
2. Lower risk of sexual side effects and weight gain than many SSRIs
3. Once-daily dosing supports adherence
4. Non-sedating and non-habit-forming

How To Use (SIVAB 7.5MG TABLETS):

1. Take once daily with a meal (minimum 300 kcal).
2. Swallow whole with water—do not crush or chew.
3. Typical titration schedule:
4. Days 1–7: 5mg once daily with food
5. Days 8–14: 7.5mg once daily with food
6. From Day 15 onward: Increase to 20mg or 40mg based on response
7. Do not discontinue abruptly—taper gradually to avoid discontinuation symptoms (dizziness, irritability, “brain zaps”).

When Not to Use (SIVAB 7.5MG TABLETS):

Do not use if you have:

1. Hypersensitivity to vilazodone
2. Concurrent or recent (within 14 days) use of MAO inhibitors
3. Uncontrolled narrow-angle glaucoma
4. Severe hepatic impairment

⚠️ Black Box Warning:

Antidepressants increase the risk of suicidal thoughts and behavior in patients under 25 years during early treatment. Close monitoring is essential.

Side Effects of (SIVAB 7.5MG TABLETS):

Common (mostly during titration):

1. Nausea, diarrhea, abdominal discomfort
2. Headache, dizziness
3. Insomnia or vivid dreams

Less common:

1. Dry mouth, fatigue
2. Mild sexual dysfunction (less frequent than with other SSRIs)
3. Minimal weight change

Serious (rare):

1. Serotonin syndrome (agitation, confusion, rapid heart rate, high fever)—especially with other serotonergic drugs
2. Hyponatremia (low sodium—more common in elderly)
3. Increased bleeding risk (with NSAIDs, aspirin, or anticoagulants)
4. Seek immediate medical help if severe GI distress, muscle rigidity, or hallucinations occur.

Dosage: (SIVAB 7.5MG TABLETS):

1. Intermediate titration dose: 7.5mg once daily with food (typically Days 8–14)
2. Maintenance dose: 20–40mg once daily (after full titration)
3. Maximum dose: 40mg/day
4. Elderly or mild hepatic impairment: Max 20mg/day; start at 5mg

Who It’s For (SIVAB 7.5MG TABLETS):

Adults with Major Depressive Disorder who are progressing through the standard vilazodone titration protocol and require a step-up from 5mg before reaching the therapeutic dose.

Warnings & Precautions:

1. Always take with food—efficacy depends on it
2. Avoid alcohol—may worsen dizziness or CNS effects
3. Screen for bipolar disorder before initiation (risk of mania)
4. Monitor closely for worsening depression or suicidal ideation, especially in the first 2 months

Drug Interactions:

1. MAO inhibitors: Contraindicated—risk of serotonin syndrome
2. Other serotonergic agents (SSRIs, SNRIs, tramadol, triptans): ↑ Serotonin syndrome risk
3. NSAIDs, warfarin, aspirin: ↑ Bleeding risk
4. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): ↑ Vilazodone levels—reduce dose
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.