Product Information:

SIVAB 5mg Tablets contain Vilazodone Hydrochloride 5mg, a serotonin modulator and stimulator (SMS) that acts as a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at 5-HT₁A receptors. This dual mechanism enhances serotonergic activity in the brain, offering antidepressant effects with a potentially favorable side effect profile—particularly regarding sexual function and weight gain.

The 5mg strength is typically used for initiating therapy to minimize gastrointestinal side effects during titration.

⚠️ Important Note:

Vilazodone must be taken with food to ensure adequate absorption. Taking it on an empty stomach reduces bioavailability by ~50%.

Uses of (SIVAB 5MG TABLETS):

1. Treatment of Major Depressive Disorder (MDD) in adults
2. Off-label: Generalized anxiety disorder (GAD), though not officially approved for this indication

Key Benefits of (SIVAB 5MG TABLETS):

1. Dual action: SSRI + 5-HT₁A partial agonism may improve onset and tolerability
2. Lower incidence of sexual dysfunction and weight gain compared to some SSRIs
3. Once-daily dosing improves adherence
4. Non-sedating and non-addictive

How To Use (SIVAB 5MG TABLETS):

1. Take once daily with a meal (minimum 300 kcal).
2. Swallow whole with water—do not crush or chew.
3. Titration schedule (standard):
4. Days 1–7: 5mg once daily with food
5. Days 8–14: Increase to 10mg once daily
6. Maintenance: Typically 20–40mg once daily (5mg is only for initiation)
7. Do not stop abruptly—taper gradually to avoid discontinuation syndrome (dizziness, irritability, "brain zaps").

When Not to Use (SIVAB 5MG TABLETS):

Do not use if you have:

1. Hypersensitivity to vilazodone
2. Concurrent use of MAO inhibitors (or within 14 days of discontinuation)
3. Uncontrolled narrow-angle glaucoma
4. Severe hepatic impairment

⚠️ Black Box Warning:

Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults (<25 years) during initial treatment. Monitor closely.

Side Effects of (SIVAB 5MG TABLETS):

Common (especially during initiation):

1. Nausea, diarrhea, vomiting
2. Headache, dizziness
3. Insomnia, abnormal dreams

Less common:

1. Sexual dysfunction (lower risk than other SSRIs)
2. Weight changes (usually minimal)
3. Dry mouth, fatigue

Serious (rare):

1. Serotonin syndrome (agitation, hallucinations, rapid heart rate, high fever)—especially with other serotonergic drugs
2. Hyponatremia (low sodium—more common in elderly)
3. Bleeding risk (with NSAIDs, aspirin, or anticoagulants)
4. Discontinue and seek help if severe GI symptoms, confusion, or muscle rigidity occur.

Dosage: (SIVAB 5MG TABLETS):

1. Starting dose: 5mg once daily with food for 7 days
2. Target dose: 20–40mg once daily (after gradual titration)
3. Maximum dose: 40mg/day
4. Elderly or mild hepatic impairment: Start at 5mg; max 20mg/day

Who It’s For (SIVAB 5MG TABLETS):

Adults diagnosed with major depressive disorder who are initiating vilazodone therapy and require a low starting dose to improve gastrointestinal tolerability.

Warnings & Precautions:

1. Always take with food
2. Avoid alcohol—may worsen CNS side effects
3. Screen for bipolar disorder before starting (may trigger mania)
4. Monitor for worsening depression or suicidal ideation, especially in first 8 weeks

Drug Interactions:

1. MAO inhibitors: Risk of serotonin syndrome—contraindicated
2. Other serotonergic drugs (SSRIs, SNRIs, triptans, tramadol): ↑ Serotonin syndrome risk
3. NSAIDs, aspirin, warfarin: ↑ Bleeding risk
4. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): ↑ Vilazodone levels—reduce dose
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.