Product Information:

SILORAP 8mg Capsules contain Silodosin 8mg, a highly selective alpha-1A adrenergic receptor antagonist used to treat moderate to severe lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in adult men. By targeting receptors primarily in the prostate and bladder neck, silodosin relaxes smooth muscle, improving urine flow and reducing bladder outlet obstruction.

This higher-strength formulation is typically used when the standard 4mg dose provides insufficient symptom relief.

⚠️ Important Note:

Silodosin is not approved for use in women or children. Women of childbearing potential should avoid handling crushed or broken capsules due to potential fetal risk.

Uses of (SILORAP 8MG CAPSULES):

1. Treatment of moderate to severe BPH symptoms, including:
2. Weak or interrupted urine stream
3. Straining to urinate
4. Sensation of incomplete bladder emptying
5. Frequent/urgent urination, nocturia (nighttime urination)

Key Benefits of (SILORAP 8MG CAPSULES):

1. Enhanced symptom control in patients not fully responsive to 4mg dose
2. High uroselectivity—minimal effect on blood pressure compared to non-selective alpha-blockers
3. Once-daily dosing for consistent 24-hour relief
4. Rapid onset of action (improvement within days)

How To Use (SILORAP 8MG CAPSULES):

1. Take one capsule (8mg) once daily with a meal (food increases absorption and reduces side effects).
2. Swallow whole with water—do not crush, chew, or open the capsule.
3. Take at the same time each day.
4. Continue therapy as prescribed, even if symptoms improve.

When Not to Use (SILORAP 8MG CAPSULES):

Do not use if you have:

1. Severe hepatic impairment (Child-Pugh C)
2. Severe renal impairment (CrCl <30 mL/min)
3. Hypersensitivity to silodosin or any excipients
4. Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin)

Side Effects of (SILORAP 8MG CAPSULES):

Common:

1. Retrograde ejaculation (dry orgasm)—dose-dependent (~25–35%), harmless but may affect fertility
2. Dizziness, headache
3. Nasal congestion, diarrhea

Less common:

1. Orthostatic hypotension (less frequent than with older alpha-blockers)
2. Fatigue, abnormal ejaculation

Serious (rare):

1. Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery—inform your ophthalmologist before any eye surgery
2. Priapism (prolonged erection >4 hours—seek emergency care)
3. Discontinue and seek medical help if vision changes or prolonged erection occur.

Dosage: (SILORAP 8MG CAPSULES):

1. Adults with normal renal/hepatic function: 8mg once daily with food
2. Mild to moderate renal impairment (CrCl ≥30 mL/min): May be used with caution
3. Severe renal or hepatic impairment: Contraindicated
4. Elderly: Generally well-tolerated; no routine dose adjustment

Who It’s For (SILORAP 8MG CAPSULES):

Adult men with moderate to severe BPH who require intensified therapy after inadequate response to the 4mg dose.

Warnings & Precautions:

1. Inform all surgeons—especially ophthalmologists—about silodosin use due to IFIS risk
2. Avoid driving or operating machinery until individual response is known
3. Use caution with other antihypertensives or PDE5 inhibitors (e.g., sildenafil)—may enhance hypotensive effects
4. Not indicated for hypertension treatment

Drug Interactions:

1. Strong CYP3A4 inhibitors: Significantly ↑ silodosin levels—avoid combination
2. Other alpha-blockers or antihypertensives: ↑ Risk of hypotension
3. PDE5 inhibitors (tadalafil, sildenafil): May cause additive blood pressure lowering
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of women and children. Do not use after the expiration date. Available by prescription only in Pakistan.