Product Information:

SILORAP 4mg Capsules contain Silodosin 4mg, a selective alpha-1A adrenergic receptor antagonist used to treat the signs and symptoms of benign prostatic hyperplasia (BPH) in adult men. By blocking alpha-1A receptors in the prostate and bladder neck, silodosin relaxes smooth muscle, improving urine flow and reducing urinary obstruction.

This formulation is specifically designed for once-daily dosing with high uroselectivity—minimizing effects on blood pressure compared to non-selective alpha-blockers.

Uses of (SILORAP 4MG CAPSULES):

1. Relief of lower urinary tract symptoms (LUTS) due to BPH, including:
2. Weak urine stream
3. Hesitancy
4. Incomplete bladder emptying
5. Frequent or urgent urination
6. Nocturia (nighttime urination)

Key Benefits of (SILORAP 4MG CAPSULES):

1. High selectivity for prostate/bladder alpha-1A receptors—less effect on vascular alpha-1B receptors
2. Rapid improvement in urine flow (within days)
3. Once-daily dosing for consistent symptom control
4. Lower risk of orthostatic hypotension compared to older alpha-blockers (e.g., terazosin)

How To Use (SILORAP 4MG CAPSULES):

1. Take one capsule (4mg) once daily with a meal (food enhances absorption and reduces side effects).
2. Swallow whole with water—do not crush, chew, or open the capsule.
3. Take at the same time each day for best results.
4. Continue therapy as prescribed—even if symptoms improve.

When Not to Use (SILORAP 4MG CAPSULES):

Do not use if you have:

1. Severe hepatic impairment (Child-Pugh C)
2. Severe renal impairment (CrCl <30 mL/min)
3. Hypersensitivity to silodosin or any excipients
4. Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)

⚠️ Note: SILORAP is for men only. Women (especially pregnant) should avoid handling crushed or broken capsules due to potential fetal harm.

Side Effects of (SILORAP 4MG CAPSULES):

Common:

1. Retrograde ejaculation (dry orgasm)—most common (~20–30%), harmless but may affect fertility
2. Dizziness, headache
3. Nasal congestion, diarrhea

Less common:

1. Orthostatic hypotension (less frequent than with non-selective alpha-blockers)
2. Ejaculation disorder, fatigue

Serious (rare):

1. Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery—inform your ophthalmologist before surgery
2. Priapism (prolonged erection—seek emergency care)
3. Discontinue and seek help if vision changes or prolonged erection occur.

Dosage: (SILORAP 4MG CAPSULES):

1. Adults with normal renal/hepatic function: 4mg once daily with food
2. Mild to moderate renal impairment (CrCl ≥30 mL/min): No dose adjustment needed
3. Severe renal or hepatic impairment: Avoid or use with extreme caution
4. Elderly: Generally well-tolerated; no routine dose change

Who It’s For (SILORAP 4MG CAPSULES):

Adult men diagnosed with moderate to severe BPH seeking relief from urinary symptoms without significant blood pressure effects.

Warnings & Precautions:

1. Inform all surgeons (especially eye surgeons) about silodosin use due to IFIS risk
2. Avoid driving or operating machinery until response is known (dizziness possible)
3. Use caution with other antihypertensives—may enhance blood pressure-lowering effects
4. Not indicated for hypertension treatment

Drug Interactions:

1. Strong CYP3A4 inhibitors (ketoconazole, clarithromycin, ritonavir): ↑ Silodosin levels—avoid combination
2. Other alpha-blockers or antihypertensives: ↑ Risk of hypotension
3. PDE5 inhibitors (sildenafil, tadalafil): May enhance hypotensive effects
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of women and children. Do not use after the expiration date. Available by prescription in Pakistan.