Product Information:

SEM-O 3mg Tablets contain Semaglutide 3mg, a GLP-1 receptor agonist. However, this formulation is highly unusual and likely incorrect.

⚠️ Critical Clarification:

Semaglutide is not available as an oral tablet in 3mg strength anywhere in the world.

1. The only approved oral semaglutide (Rybelsus®) comes in 3mg, 7mg, and 14mg tablets—but 3mg is a STARTING dose, not a maintenance dose.
2. Oral semaglutide must be taken on an empty stomach with only water, and requires special absorption enhancers (SNAC).
3. However, "SEM-O" naming suggests an oral product, which aligns with Rybelsus®-like formulations.

✅ Most Probable Identity:

Oral Semaglutide 3mg – the initial titration dose for type 2 diabetes.

❗ Important: Despite the name "SEM-O 3MG TABS," confirm with your pharmacist whether this is indeed oral semaglutide, as counterfeit or mislabeled products exist.

Assuming it is genuine oral semaglutide 3mg, the following applies:

Uses of (SEM-O 3MG TABS):

1. Type 2 diabetes mellitus – as part of initial dose escalation
2. Not for weight loss (oral semaglutide is approved only for diabetes, not obesity)

Key Benefits:

1. First and only oral GLP-1 receptor agonist
2. Improves glycemic control without injections
3. Promotes modest weight loss (~3–5 kg)
4. Low risk of hypoglycemia when used alone

How To Use (SEM-O 3MG TABS):

1. Take once daily in the morning, on an empty stomach
2. Swallow with only a small sip of plain water (≤120 mL)
3. Wait at least 30 minutes before eating, drinking, or taking other medications
4. Do not split, crush, or chew the tablet

Dosing Protocol:

1. Weeks 1–30: Start with 3mg once daily
2. After ≥30 days: May increase to 7mg or 14mg based on response
3. 3mg is not a maintenance dose—used only for initiation

When Not to Use:

1. Type 1 diabetes or diabetic ketoacidosis
2. Personal/family history of medullary thyroid carcinoma (MTC)
3. MEN 2 syndrome
4. Hypersensitivity to semaglutide

⚠️ Black Box Warning:

Causes thyroid C-cell tumors in rodents—contraindicated in patients at risk for MTC.

Side Effects:

Common:

1. Nausea, vomiting, diarrhea, abdominal pain
2. Decreased appetite
3. Constipation

Serious (rare):

1. Pancreatitis (severe persistent abdominal pain)
2. Diabetic retinopathy complications
3. Acute kidney injury (from dehydration)
4. Gallbladder disease

Seek medical help if severe abdominal pain or vision changes occur.

Warnings & Precautions:

1. Ensure adequate hydration
2. Monitor renal function
3. Use caution in patients with diabetic retinopathy
4. Not for use in pregnancy unless clearly needed

Drug Interactions:

1. May delay absorption of other oral drugs—take ≥30 min apart
2. Risk of hypoglycemia with insulin/sulfonylureas

Additional Information:

Store below 30°C in original blister pack. Keep out of reach of children. Prescription-only in Pakistan.