Product Information:

SAVESTO 100mg (49mg + 51mg) Tablets contain a fixed-dose combination of:

1. Diosmin 49mg
2. Hesperidin 51mg

Together, these bioflavonoids form a micronized purified flavonoid fraction (MPFF) totaling 100mg per tablet. This formulation improves venous tone, reduces capillary permeability, and enhances lymphatic drainage, making it effective in managing chronic venous insufficiency and hemorrhoidal disease.

⚠️ Note: While higher strengths (e.g., 500mg diosmin + 50mg hesperidin) are common globally, SAVESTO 100mg is a low-dose formulation, likely intended for maintenance therapy, pediatric use (off-label), or mild symptoms in the Pakistani market.

Uses of (SAVESTO 100MG 49MG+51MG TABLETS):

1. Symptomatic treatment of chronic venous insufficiency (leg heaviness, pain, swelling, cramps, itching)
2. Management of acute and chronic hemorrhoids (bleeding, pain, swelling)
3. Adjunct in post-thrombotic syndrome and varicose veins
4. Prevention of symptom recurrence after hemorrhoidectomy

Key Benefits of (SAVESTO 100MG 49MG+51MG TABLETS):

1. Reduces venous stasis and capillary fragility
2. Decreases edema and inflammation in venous disorders
3. Improves microcirculation and lymphatic drainage
4. Well-tolerated with minimal systemic side effects

How To Use (SAVESTO 100MG 49MG+51MG TABLETS):

1. Take as directed by your physician.
2. Typical regimens may include:
3. Chronic venous insufficiency: 1–2 tablets twice daily
4. Acute hemorrhoidal attack: Higher doses (e.g., 6 tablets/day) for 4 days, then taper—but SAVESTO 100mg is likely for maintenance only
5. Swallow whole with water, preferably with meals to enhance absorption.
6. Duration: Short-term for acute hemorrhoids; long-term for chronic venous disease.

When Not to Use (SAVESTO 100MG 49MG+51MG TABLETS):

Do not use if you have:

1. Hypersensitivity to diosmin, hesperidin, or any excipients
2. Known allergy to citrus bioflavonoids
3. Severe hepatic or renal impairment (use with caution)

Side Effects of (SAVESTO 100MG 49MG+51MG TABLETS):

Common: Mild gastrointestinal discomfort, nausea, diarrhea.

Rare: Headache, dizziness, skin rash.

Serious (very rare): Allergic reactions (urticaria, angioedema).

Discontinue if hypersensitivity occurs.

Dosage: (SAVESTO 100MG 49MG+51MG TABLETS):

1. Adults: Typically 1–2 tablets twice daily for maintenance
2. Acute hemorrhoids: May require higher total daily dose (consult doctor—this low-strength tablet may need multiple units)
3. Children: Not established; use only under specialist guidance

Who It’s For (SAVESTO 100MG 49MG+51MG TABLETS):

1. Adults with mild chronic venous insufficiency
2. Patients requiring long-term maintenance therapy after acute treatment
3. Individuals seeking vein health support with a low-dose flavonoid option

Warnings & Precautions:

1. Not a substitute for compression therapy or lifestyle changes (e.g., leg elevation, exercise)
2. Rule out deep vein thrombosis (DVT) before treating leg swelling
3. Use cautiously in pregnancy—limited safety data (though flavonoids are generally considered low risk)

Drug Interactions:

1. Minimal systemic absorption → low interaction potential
2. Theoretical interaction with anticoagulants (e.g., warfarin)—monitor INR if combined
3. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available over-the-counter or by prescription in Pakistan.