Product Information:

ROXAGET 70mg Tablets contain Risedronate Sodium 70mg, a bisphosphonate medication used to treat and prevent osteoporosis. It works by inhibiting osteoclast-mediated bone resorption, thereby increasing bone mineral density and reducing the risk of fractures—particularly in the spine and hip.

The 70mg once-weekly formulation is designed for convenience and improved adherence compared to daily dosing.

Uses of (ROXAGET 70MG TABS):

1. Treatment and prevention of postmenopausal osteoporosis
2. Treatment of osteoporosis in men
3. Glucocorticoid-induced osteoporosis (in patients on long-term steroid therapy)
4. Paget’s disease of bone (off-label or in specific formulations)

Key Benefits of (ROXAGET 70MG TABS):

1. Once-weekly dosing improves patient compliance
2. Proven reduction in vertebral and non-vertebral fracture risk
3. Increases bone mineral density within 6–12 months
4. Well-tolerated with minimal systemic absorption

How To Use (ROXAGET 70MG TABS):

1. Take once weekly, on the same day each week, first thing in the morning.
2. Swallow whole with a full glass (≥200 mL) of plain water—do not use mineral water, coffee, juice, or tea.
3. Take at least 30 minutes before the first food, beverage (other than water), or other medication of the day.
4. Remain upright (sitting or standing) for at least 30 minutes after taking to reduce esophageal irritation.
5. Do not lie down until after your first meal.

⚠️ Critical: Failure to follow these instructions may reduce absorption and increase risk of esophageal injury.

When Not to Use (ROXAGET 70MG TABS):

Do not use if you have:

1. Hypersensitivity to risedronate or any excipients
2. Esophageal stricture, achalasia, or delayed esophageal emptying
3. Inability to stand or sit upright for 30 minutes
4. Hypocalcemia (correct calcium levels before starting)
5. Severe renal impairment (CrCl <30 mL/min)

Side Effects of (ROXAGET 70MG TABS):

Common:

1. Headache, mild gastrointestinal upset
2. Constipation or diarrhea
3. Muscle or joint pain

Less common:

1. Esophagitis, dysphagia, gastric ulcers (if dosing instructions not followed)
2. Transient hypocalcemia (ensure adequate calcium/vitamin D intake)

Serious (rare):

1. Osteonecrosis of the jaw (ONJ)—especially after dental surgery; inform dentist before procedures
2. Atypical femoral fracture (unexplained thigh/groin pain)—discontinue if occurs
3. Severe esophageal reactions (ulceration, strictures)—if taken incorrectly
4. Seek medical help if jaw pain, thigh pain, or swallowing difficulties develop.

Dosage: (ROXAGET 70MG TABS):

1. Adults: 70mg once weekly
2. Not for daily use
3. Ensure adequate calcium (1000–1200 mg/day) and vitamin D (800–1000 IU/day) intake

Who It’s For (ROXAGET 70MG TABS):

Postmenopausal women, men with osteoporosis, or patients on long-term glucocorticoids who require bone protection and can adhere to strict dosing instructions.

Warnings & Precautions:

1. Maintain good dental hygiene and have dental check-ups before starting
2. Monitor for thigh/groin pain—may indicate atypical femur fracture
3. Correct hypocalcemia before initiation
4. Use caution in patients with upper GI disorders

Drug Interactions:

1. Calcium supplements, antacids, iron: ↓ Absorption—take at least 30 minutes apart
2. NSAIDs: May increase GI irritation risk
3. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.