Product Information:

ROXAGET 20mg Tablets contain Roxithromycin 20mg, a low-dose formulation of a semi-synthetic macrolide antibiotic. Roxithromycin inhibits bacterial protein synthesis and is effective against a range of Gram-positive bacteria and atypical pathogens such as Mycoplasma, Chlamydia, and Legionella.

This pediatric or titration-strength formulation is primarily intended for children, infants, or adults requiring precise low-dose therapy, especially in regions like Pakistan where tailored dosing for lower body weight is essential.

⚠️ Note: Roxithromycin 20mg tablets are uncommon globally but may be available in select markets (including Pakistan) to facilitate accurate dosing in young children.

Uses of (ROXAGET 20MG TABLETS):

1. Respiratory tract infections in children: pharyngitis, tonsillitis, bronchitis, pneumonia
2. Otitis media (middle ear infection)
3. Skin and soft tissue infections (e.g., impetigo)
4. Non-gonococcal urethritis (in adolescents/adults, though higher doses are typically used)

Key Benefits of (ROXAGET 20MG TABLETS):

1. Enables precise weight-based dosing in pediatric patients
2. Better gastrointestinal tolerance than erythromycin
3. Once- or twice-daily dosing due to long half-life
4. Suitable alternative for penicillin-allergic patients

How To Use (ROXAGET 20MG TABLETS):

1. Administer on an empty stomach (15 minutes before or 2 hours after meals) for optimal absorption.
2. Swallow whole with water—may be crushed for young children if advised by a doctor.
3. Pediatric dosage:
4. 4–8 mg/kg/day in 1–2 divided doses
5. Example: A 10kg child may receive 40–80mg/day → 2–4 tablets of 20mg daily
6. Complete the full course even if symptoms improve early.

When Not to Use (ROXAGET 20MG TABLETS):

Do not use if the patient has:

1. Hypersensitivity to roxithromycin, erythromycin, or other macrolides
2. History of QT prolongation or cardiac arrhythmias
3. Concurrent use of ergot alkaloids or cisapride
4. Severe hepatic impairment

Side Effects of (ROXAGET 20MG TABLETS):

Common: Nausea, vomiting, abdominal pain, diarrhea, loss of appetite (especially in children).

Less common: Rash, headache, elevated liver enzymes.

Serious (rare):

1. QT prolongation (risk increases with overdose or underlying heart conditions)
2. Severe liver injury (jaundice, dark urine)
3. Clostridioides difficile-associated diarrhea
4. Discontinue and seek medical help if severe diarrhea, jaundice, or irregular heartbeat occurs.

Dosage: (ROXAGET 20MG TABLETS):

1. Children: 4–8 mg/kg/day in 1–2 divided doses
2. Max daily dose: Typically not exceeding 300mg/day
3. Adults: Not typically treated with 20mg strength; higher doses (150–300mg/day) are standard
4. Duration: 5–10 days, depending on infection

Who It’s For (ROXAGET 20MG TABLETS):

1. Infants and children (≥6 months) requiring antibiotic therapy
2. Patients needing flexible dosing due to low body weight
3. Penicillin-allergic individuals with mild to moderate infections

Warnings & Precautions:

1. Avoid in patients with known prolonged QT interval
2. Use cautiously in liver disease—monitor for jaundice
3. Do not use for viral infections (e.g., common cold, flu)
4. Ensure accurate weight-based dosing to avoid under- or overdosing

Drug Interactions:

1. Cisapride, pimozide: ↑ Risk of serious arrhythmias—avoid
2. Ergotamine: Risk of vasospasm
3. Theophylline, carbamazepine: Roxithromycin may increase their blood levels
4. Warfarin: May enhance anticoagulant effect—monitor INR
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.