Product Information:

ROXAGET 100mg Tablets contain Roxithromycin 100mg, a semi-synthetic macrolide antibiotic derived from erythromycin. It works by inhibiting bacterial protein synthesis, thereby stopping the growth of susceptible bacteria. Roxithromycin has improved acid stability and better tissue penetration compared to erythromycin, with a longer half-life allowing once- or twice-daily dosing.

This formulation is used to treat mild to moderate infections caused by susceptible organisms.

Uses of (ROXAGET 100MG TABLETS):

1. Respiratory tract infections: Pharyngitis, tonsillitis, sinusitis, bronchitis, pneumonia
2. Skin and soft tissue infections: Impetigo, folliculitis, cellulitis
3. Genitourinary infections: Non-gonococcal urethritis (caused by Chlamydia trachomatis)
4. Dental infections and otitis media (as an alternative in penicillin-allergic patients)

Key Benefits of (ROXAGET 100MG TABLETS):

1. Effective against Gram-positive bacteria and atypical pathogens (Mycoplasma, Chlamydia, Legionella)
2. Better gastrointestinal tolerance than erythromycin
3. Longer half-life allows convenient dosing (once or twice daily)
4. Suitable for patients with penicillin allergy

How To Use (ROXAGET 100MG TABLETS):

1. Take on an empty stomach (at least 15 minutes before or 2 hours after meals) for optimal absorption.
2. Swallow whole with water—do not crush or chew.
3. Typical adult dose:
4. Standard infections: 150mg twice daily or 300mg once daily
5. ROXAGET 100mg tablets are often used in children or for dose titration
6. Complete the full course even if symptoms improve early.

⚠️ Note: ROXAGET 100mg is typically prescribed as 1–2 tablets per dose, depending on infection severity and patient weight.

When Not to Use (ROXAGET 100MG TABLETS):

Do not use if you have:

1. Hypersensitivity to roxithromycin, erythromycin, or other macrolides
2. History of QT prolongation or cardiac arrhythmias
3. Concurrent use of ergot alkaloids (e.g., ergotamine) or cisapride
4. Severe hepatic impairment

Side Effects of (ROXAGET 100MG TABLETS):

Common: Nausea, abdominal pain, diarrhea, vomiting, headache.

Less common: Dizziness, rash, elevated liver enzymes.

Serious (rare):

1. QT prolongation → risk of torsades de pointes (especially with high doses or cardiac risk)
2. Severe liver injury (cholestatic hepatitis)
3. Clostridioides difficile-associated diarrhea
4. Allergic reactions (rash, anaphylaxis)
5. Discontinue and seek medical help if severe diarrhea, jaundice, or irregular heartbeat occurs.

Dosage: (ROXAGET 100MG TABLETS):

1. Adults: 150mg twice daily or 300mg once daily
2. Children (≥6 years): 4–8 mg/kg/day in 1–2 divided doses (often using 100mg tablets for dosing flexibility)
3. Duration: Typically 5–10 days, depending on infection type

Who It’s For (ROXAGET 100MG TABLETS):

1. Adults and children with mild to moderate bacterial infections
2. Penicillin-allergic patients requiring alternative therapy
3. Those needing outpatient treatment for respiratory or skin infections

Warnings & Precautions:

1. Avoid in patients with known prolonged QT interval
2. Use cautiously in hepatic impairment—monitor liver function
3. May worsen myasthenia gravis
4. Do not use for viral infections (e.g., common cold, flu)

Drug Interactions:

1. Cisapride, pimozide, quinidine: ↑ Risk of QT prolongation—avoid combination
2. Ergot alkaloids: Risk of ergotism (vasospasm, ischemia)
3. Warfarin: May ↑ INR—monitor closely
4. Theophylline, carbamazepine: Roxithromycin may ↑ their levels
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.