Product Information:

ROVISTA EZ 5+10 Tablets is a fixed-dose combination containing:

1. Rosuvastatin 5mg – a statin that inhibits cholesterol synthesis in the liver
2. Ezetimibe 10mg – a cholesterol absorption inhibitor that blocks intestinal uptake of dietary and biliary cholesterol

This low-intensity dual-mechanism therapy provides additive lipid-lowering effects with a favorable safety profile, making it ideal for initiating combination therapy, elderly patients, or individuals of South Asian descent (including Pakistani patients) who may be more sensitive to statins.

Uses of (ROVISTA EZ 5+10 TABLETS):

1. Treatment of primary hyperlipidemia or mixed dyslipidemia when lifestyle changes are insufficient
2. Primary prevention in patients with moderate cardiovascular risk
3. Patients requiring combination therapy but at increased risk of statin-related side effects (e.g., elderly, diabetic, renal impairment)
4. Those with statin intolerance at higher doses

Key Benefits of (ROVISTA EZ 5+10 TABLETS):

1. Reduces LDL-C by approximately 45–50%—greater than either drug alone
2. Dual action: targets both liver production and intestinal absorption of cholesterol
3. Lower rosuvastatin dose minimizes muscle and liver-related side effects
4. Once-daily dosing improves adherence

How To Use (ROVISTA EZ 5+10 TABLETS):

1. Take one tablet once daily, with or without food, at the same time each day.
2. Swallow whole with water—do not crush or chew.
3. Continue a heart-healthy, low-saturated-fat diet and regular physical activity.
4. Lipid profile should be checked 4–12 weeks after starting and periodically thereafter.

When Not to Use (ROVISTA EZ 5+10 TABLETS):

Do not use if you have:

1. Active liver disease or unexplained persistent elevations in liver enzymes
2. Hypersensitivity to rosuvastatin, ezetimibe, or any excipients
3. Pregnancy or breastfeeding (contraindicated)
4. Concurrent use of cyclosporine

⚠️ Special Note for Pakistani Patients:

South Asians often achieve significant LDL reduction at lower statin doses. ROVISTA EZ 5+10 is a preferred starting combination to balance efficacy and safety.

Side Effects of (ROVISTA EZ 5+10 TABLETS):

Common: Headache, mild muscle aches, abdominal discomfort, diarrhea, fatigue.

Rare: Dizziness, rash, slight elevation in liver enzymes.

Serious (very rare at this dose):

1. Myopathy: Unexplained muscle pain, tenderness, or weakness
2. Liver dysfunction: Jaundice, dark urine, unusual tiredness
3. Hypersensitivity reactions: Skin rash, angioedema (ezetimibe-related)
4. Discontinue and seek medical help if severe muscle symptoms or signs of liver injury occur.

Dosage: (ROVISTA EZ 5+10 TABLETS):

1. Adults: One tablet (rosuvastatin 5mg + ezetimibe 10mg) once daily
2. Elderly or mild renal impairment: Safe as starting dose
3. Severe hepatic impairment: Contraindicated

Who It’s For (ROVISTA EZ 5+10 TABLETS):

1. Adults initiating combination lipid-lowering therapy
2. Elderly patients or those with comorbidities (diabetes, kidney disease)
3. Individuals of South Asian origin (including Pakistanis)
4. Patients with moderate cardiovascular risk needing LDL-C reduction >40%

Warnings & Precautions:

1. Monitor liver function tests (LFTs) before and during therapy if clinically indicated
2. Report any unexplained muscle pain or weakness promptly
3. Avoid excessive alcohol consumption
4. Inform your doctor before surgery or if starting new medications

Drug Interactions:

1. Cyclosporine: ↑ Levels of both drugs—avoid combination
2. Fibrates: May ↑ risk of myopathy—use with caution
3. Warfarin: Rosuvastatin may slightly ↑ INR; ezetimibe has minimal interaction
4. Bile acid sequestrants (e.g., cholestyramine): Take ezetimibe 2 hours before or 4 hours after
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.