Product Information:

ROVISTA 5mg Tablets contain Rosuvastatin Calcium 5mg, a potent HMG-CoA reductase inhibitor (statin) that lowers cholesterol by inhibiting the enzyme responsible for cholesterol synthesis in the liver. This leads to reduced levels of low-density lipoprotein cholesterol (LDL-C or “bad” cholesterol), triglycerides, and a modest increase in high-density lipoprotein cholesterol (HDL-C or “good” cholesterol).

This low-to-moderate strength is ideal for initiating therapy, elderly patients, those with comorbidities, or individuals of South Asian descent (including Pakistani patients), who may have higher systemic exposure to rosuvastatin.

Uses of (ROVISTA 5MG TABLETS):

1. Treatment of primary hyperlipidemia (elevated LDL-C and triglycerides)
2. Management of mixed dyslipidemia (Fredrickson Type IIa and IIb)
3. Primary and secondary prevention of cardiovascular events (heart attack, stroke) in moderate-risk patients
4. Adjunct to diet and lifestyle modifications in patients with metabolic syndrome or type 2 diabetes

Key Benefits of (ROVISTA 5MG TABLETS):

1. Reduces LDL-C by 30–40% on average
2. Lowers long-term risk of atherosclerotic cardiovascular disease
3. Once-daily dosing for consistent adherence
4. Well-tolerated starting dose with lower risk of side effects

How To Use (ROVISTA 5MG TABLETS):

1. Take once daily, with or without food, at the same time each day (evening preferred but not required).
2. Swallow whole with water—do not crush or chew.
3. Continue a heart-healthy diet, regular exercise, and weight management while on therapy.
4. Lipid profile should be checked 4–12 weeks after starting and periodically thereafter.

When Not to Use (ROVISTA 5MG TABLETS):

Do not use if you have:

1. Active liver disease or unexplained persistent elevations in liver enzymes
2. Hypersensitivity to rosuvastatin or any excipients
3. Pregnancy or breastfeeding (statins are contraindicated)
4. Concurrent use of cyclosporine

⚠️ Special Note for Pakistani Patients:

South Asians often achieve greater lipid-lowering at lower doses. 5mg is a recommended starting dose to minimize side effects while maintaining efficacy.

Side Effects of (ROVISTA 5MG TABLETS):

Common: Headache, mild muscle aches, nausea, abdominal discomfort, constipation.

Rare: Dizziness, rash, slight elevation in liver enzymes.

Serious (very rare at this dose):

1. Myopathy: Unexplained muscle pain, tenderness, or weakness
2. Liver dysfunction: Jaundice, fatigue, dark urine
3. Increased blood sugar (small risk with long-term use)
4. Discontinue and seek medical help if severe muscle symptoms or signs of liver injury occur.

Dosage: (ROVISTA 5MG TABLETS):

1. Adults: 5–20mg once daily
2. Starting dose (especially in South Asians, elderly, or renal impairment): 5mg once daily
3. Maintenance: May increase to 10–20mg based on response and tolerance
4. Maximum dose: 20mg/day (40mg is restricted due to safety concerns)

Who It’s For (ROVISTA 5MG TABLETS):

1. Adults initiating statin therapy
2. Elderly patients or those with kidney impairment
3. Individuals of South Asian origin (including Pakistanis)
4. Patients with moderate cardiovascular risk or mild-moderate hypercholesterolemia

Warnings & Precautions:

1. Monitor liver function tests (LFTs) before starting and as clinically indicated
2. Report any unexplained muscle pain or weakness immediately
3. Avoid excessive alcohol consumption
4. Inform your doctor before surgery or if starting new medications (e.g., fibrates, colchicine)

Drug Interactions:

1. Cyclosporine: Significantly ↑ rosuvastatin levels—avoid combination
2. Fibrates (e.g., fenofibrate): ↑ Risk of muscle-related side effects
3. Warfarin: May slightly ↑ INR—monitor if combined
4. Antacids: Reduce absorption—take 2 hours apart
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.