Product Information:

ROVISTA 20mg Tablets contain Rosuvastatin Calcium 20mg, a potent HMG-CoA reductase inhibitor (statin) that lowers cholesterol by blocking the enzyme responsible for cholesterol production in the liver. This leads to reduced levels of low-density lipoprotein cholesterol (LDL-C or “bad” cholesterol), triglycerides, and increased high-density lipoprotein cholesterol (HDL-C or “good” cholesterol).

This intermediate-to-high strength is used for patients requiring significant lipid-lowering to reduce cardiovascular risk.

Uses of (ROVISTA 20MG TABLETS):

1. Treatment of primary hyperlipidemia (elevated LDL-C and triglycerides)
2. Management of mixed dyslipidemia (Fredrickson Type IIa and IIb)
3. Prevention of cardiovascular events (heart attack, stroke) in high-risk patients (e.g., diabetes, hypertension, existing atherosclerosis)
4. Adjunct to diet and lifestyle changes in homozygous familial hypercholesterolemia (with other lipid-lowering therapies)

Key Benefits of (ROVISTA 20MG TABLETS):

1. Reduces LDL-C by up to 50–60%
2. Lowers risk of heart attack, stroke, and need for revascularization
3. Once-daily dosing for improved adherence
4. Effective across a broad range of dyslipidemias

How To Use (ROVISTA 20MG TABLETS):

1. Take once daily, with or without food, at the same time each day (evening preferred but not required).
2. Swallow whole with water—do not crush or chew.
3. Continue a heart-healthy diet and exercise plan while on therapy.
4. Lipid levels should be monitored 4–12 weeks after starting or dose change.

When Not to Use (ROVISTA 20MG TABLETS):

Do not use if you have:

1. Active liver disease or unexplained persistent elevations in liver enzymes
2. Hypersensitivity to rosuvastatin or any excipients
3. Pregnancy or breastfeeding (statins are contraindicated)
4. Concurrent use of cyclosporine (increases rosuvastatin blood levels significantly)

⚠️ Dose Limitation:

In Pakistani patients (of South Asian descent), start with lower doses due to higher systemic exposure. 20mg should only be used if lower doses (5–10mg) are insufficient and well-tolerated.

Side Effects of (ROVISTA 20MG TABLETS):

Common: Headache, muscle aches, nausea, abdominal pain, constipation.

Rare: Dizziness, rash, elevated liver enzymes.

Serious (rare but require monitoring):

1. Myopathy/Rhabdomyolysis: Unexplained muscle pain, tenderness, or weakness—especially with fever or dark urine
2. Liver injury: Jaundice, fatigue, right upper quadrant pain
3. New-onset diabetes (small increased risk with long-term high-dose statins)
4. Discontinue and seek medical help if severe muscle symptoms or signs of liver dysfunction occur.

Dosage: (ROVISTA 20MG TABLETS):

1. Adults: 5–20mg once daily
2. Starting dose: Usually 5–10mg; escalate to 20mg only if needed
3. Maximum dose: 20mg/day (40mg is restricted due to safety concerns)
4. Elderly or renal impairment: Start at 5mg; use 20mg with caution

Who It’s For (ROVISTA 20MG TABLETS):

Adults with high cardiovascular risk or severe hypercholesterolemia who require aggressive LDL-C lowering and have tolerated lower doses of rosuvastatin.

Warnings & Precautions:

1. Monitor liver function tests (LFTs) before and during therapy
2. Check creatine kinase (CK) if muscle symptoms develop
3. Avoid excessive alcohol consumption
4. Inform your doctor before surgery or if starting new medications (e.g., fibrates, colchicine)

Drug Interactions:

1. Cyclosporine: ↑ Rosuvastatin levels—avoid 20mg dose
2. Fibrates (e.g., fenofibrate): ↑ Risk of myopathy
3. Warfarin: May slightly ↑ INR—monitor closely
4. Antacids: Reduce absorption—take 2 hours apart
5. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.