Product Information:

RISPERIGET 2mg Tablets contain Risperidone 2mg, a second-generation (atypical) antipsychotic that acts primarily as a dopamine D₂ and serotonin 5-HT₂A receptor antagonist. It is used to manage symptoms of psychotic and mood disorders by restoring the balance of neurotransmitters in the brain.

This intermediate-strength formulation is commonly used for schizophrenia, bipolar mania, and irritability associated with autism in adults and adolescents.

Uses of (RISPERIGET 2MG TABLETS):

1. Treatment of schizophrenia in adults and adolescents (≥13 years)
2. Short-term management of acute manic or mixed episodes in bipolar I disorder (monotherapy or with lithium/valproate)
3. Management of irritability, aggression, self-injury, and mood swings in autistic children (≥5 years)
4. Off-label: Adjunct in treatment-resistant depression, delusional disorder, or behavioral disturbances in dementia (use with extreme caution)

Key Benefits of (RISPERIGET 2MG TABLETS):

1. Effective control of positive (hallucinations, delusions) and negative (social withdrawal, apathy) symptoms of schizophrenia
2. Mood-stabilizing effects in bipolar mania
3. Once- or twice-daily dosing improves adherence
4. Lower risk of extrapyramidal side effects (EPS) than first-generation antipsychotics (at low doses)

How To Use (RISPERIGET 2MG TABLETS):

1. Take once or twice daily, with or without food, as directed by your psychiatrist.
2. Swallow whole with water—do not crush or chew.
3. Dosing is individualized:
4. Schizophrenia: Often started at 2mg/day, titrated based on response
5. Bipolar mania: 2–6mg/day in divided doses
6. Autism (children): Lower starting doses (0.25–0.5mg), gradually increased
7. Do not stop abruptly—taper under medical supervision to avoid rebound psychosis or insomnia.

When Not to Use (RISPERIGET 2MG TABLETS):

Do not use if you have:

1. Hypersensitivity to risperidone or paliperidone
2. Known history of neuroleptic malignant syndrome (NMS)
3. Severe cardiovascular disease or risk of stroke (especially in elderly with dementia-related psychosis)
4. Concurrent use of drugs that prolong QT interval

⚠️ Black Box Warning:

Elderly patients with dementia-related psychosis treated with antipsychotics are at increased risk of death (from heart-related events or infections). Risperidone is not approved for this population.

Side Effects of (RISPERIGET 2MG TABLETS):

Common:

1. Drowsiness, dizziness, fatigue
2. Weight gain, increased appetite
3. Dry mouth, constipation
4. Mild tremor or restlessness

Serious (require monitoring):

1. Extrapyramidal symptoms (EPS): Muscle stiffness, tremors, akathisia (more likely at higher doses)
2. Hyperprolactinemia: Galactorrhea, menstrual irregularities, sexual dysfunction
3. Metabolic effects: Hyperglycemia, dyslipidemia, significant weight gain
4. Orthostatic hypotension (especially during initiation)
5. Tardive dyskinesia (involuntary movements—may be irreversible)
6. Discontinue and seek help if high fever, muscle rigidity, or uncontrolled movements occur.

Dosage: (RISPERIGET 2MG TABLETS):

1. Adults (schizophrenia): 2–6mg/day (starting at 2mg)
2. Adolescents (13–17 years): 0.5–3mg/day
3. Bipolar mania: 2–6mg/day
4. Autism (5–17 years): 0.5–3mg/day (max 6mg/day in rare cases)
5. Elderly or hepatic/renal impairment: Start at 0.5mg twice daily

Who It’s For (RISPERIGET 2MG TABLETS):

Adults and adolescents diagnosed with schizophrenia, bipolar I disorder (manic phase), or autism-related irritability, under ongoing psychiatric care.

Warnings & Precautions:

1. Monitor weight, blood glucose, and lipids regularly
2. Assess for movement disorders at each visit
3. Avoid driving or operating machinery until response is known
4. Use extreme caution in elderly patients—increased risk of stroke and mortality
5. Screen for diabetes and cardiovascular risk before and during treatment

Drug Interactions:

1. CNS depressants (alcohol, benzodiazepines): ↑ Sedation
2. Carbamazepine: May reduce risperidone levels
3. Fluoxetine, paroxetine: May ↑ risperidone levels—dose adjustment needed
4. Antihypertensives: ↑ Risk of orthostatic hypotension
5. Always inform your psychiatrist about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription only in Pakistan.