Product Information:

RISEK INSTA 40mg Sachet contains Rabeprazole Sodium 40mg in a granule formulation for oral suspension, designed for patients who have difficulty swallowing capsules—such as the elderly, those with dysphagia, post-stroke, or post-surgical patients. The granules are enteric-coated to protect the drug from gastric acid and ensure targeted release in the small intestine for optimal absorption.

This higher-strength formulation is used for severe gastroesophageal reflux disease (GERD), erosive esophagitis, refractory ulcers, or as part of high-dose H. pylori eradication regimens.

Uses of (RISEK INSTA 40MG SACHET):

1. Treatment of severe GERD with erosive esophagitis
2. Healing of refractory gastric or duodenal ulcers
3. Helicobacter pylori eradication (as part of high-dose triple or quadruple therapy)
4. Management of NSAID-induced ulcer complications in high-risk patients
5. Acid suppression in patients unable to take oral capsules

Key Benefits of (RISEK INSTA 40MG SACHET):

1. Higher dose for enhanced acid control in severe conditions
2. Easy administration for patients with swallowing difficulties
3. Rapid and sustained gastric acid suppression (onset within 1–2 hours)
4. Once-daily dosing improves adherence
5. Maintains full therapeutic efficacy of rabeprazole

How To Use (RISEK INSTA 40MG SACHET):

1. Empty the entire contents of one sachet into 15–30 mL of room-temperature water (do not use hot, acidic, or carbonated liquids).
2. Stir gently and drink immediately—do not store for later use.
3. Take once daily, preferably 30–60 minutes before breakfast.
4. For H. pylori eradication: May be prescribed twice daily (morning and evening) with antibiotics for 10–14 days.
5. Do not chew or crush the granules.

When Not to Use (RISEK INSTA 40MG SACHET):

Do not use if you have:

1. Hypersensitivity to rabeprazole or other proton pump inhibitors (e.g., omeprazole, pantoprazole)
2. Concurrent use of atazanavir or rilpivirine (HIV medications)
3. Severe hepatic impairment (use with caution; consider lower dose)

Side Effects of (RISEK INSTA 40MG SACHET):

Common: Headache, diarrhea, abdominal pain, nausea, flatulence.

Rare: Dizziness, rash, dry mouth, vitamin B12 or magnesium deficiency (with prolonged use >1 year).

Serious (rare):

1. Clostridioides difficile-associated diarrhea
2. Osteoporosis-related fractures (hip, wrist, spine)
3. Hypomagnesemia (muscle spasms, seizures, arrhythmias)
4. Acute interstitial nephritis (fever, rash, reduced urine output)
5. Discontinue and seek medical help if severe diarrhea, bone pain, or irregular heartbeat occurs.

Dosage: (RISEK INSTA 40MG SACHET):

1. Severe GERD / Erosive Esophagitis: One sachet (40mg) once daily for 4–8 weeks
2. H. pylori Eradication: One sachet twice daily + two antibiotics for 10–14 days
3. Elderly or mild hepatic impairment: No routine dose adjustment needed
4. Maximum duration: Use the lowest effective dose for the shortest time necessary

Who It’s For (RISEK INSTA 40MG SACHET):

1. Adults with severe or treatment-resistant acid-related disorders
2. Elderly or neurologically impaired patients who cannot swallow capsules
3. Those requiring high-dose PPI therapy but needing alternative oral formulation

Warnings & Precautions:

1. Use only when clinically indicated—avoid long-term use without supervision
2. Monitor serum magnesium, vitamin B12, and bone mineral density if used >1 year
3. May mask symptoms of gastric malignancy—investigate persistent dyspepsia
4. Avoid mixing with hot, acidic, or carbonated beverages

Drug Interactions:

1. Atazanavir, rilpivirine: ↓ Absorption—contraindicated
2. Clopidogrel: Rabeprazole has minimal interaction (safer than omeprazole)
3. Methotrexate, iron, digoxin, ketoconazole: Altered absorption due to increased gastric pH
4. Always inform your doctor about all medications and supplements.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.