Product Information:

RESMIROM 100mg Tablets contain Resmetirom 100mg, a first-in-class, selective thyroid hormone receptor-β (THR-β) agonist. It is indicated for the treatment of non-alcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults.

Resmetirom works by activating THR-β in the liver, which enhances mitochondrial fat metabolism, reduces hepatic fat accumulation, and decreases inflammation and fibrosis—without significantly affecting the heart or bones (which are influenced by THR-α).

⚠️ Important Note:

Resmetirom (brand name Rezdiffra™) was approved by the U.S. FDA in March 2024 as the first drug specifically for NASH with fibrosis. As of 2026, it may be newly available or under restricted access in Pakistan. Confirm regulatory status with local health authorities.

Uses of (RESMIROM 100MG TABLETS):

1. Treatment of non-alcoholic steatohepatitis (NASH) confirmed by biopsy or non-invasive testing
2. Management of moderate to advanced liver fibrosis (F2–F3) due to metabolic dysfunction-associated steatotic liver disease (MASLD)
3. Reduction of liver fat, inflammation, and progression to cirrhosis

Key Benefits of (RESMIROM 100MG TABLETS):

1. First FDA-approved therapy targeting NASH with fibrosis
2. Improves liver histology (fat, inflammation, ballooning, fibrosis)
3. Reduces cardiovascular risk markers (LDL cholesterol, triglycerides)
4. Oral once-daily dosing with liver-targeted action
5. Minimal systemic thyroid effects (due to THR-β selectivity)

How To Use (RESMIROM 100MG TABLETS):

1. Take one tablet once daily with food (to enhance absorption).
2. Swallow whole with water—do not crush or chew.
3. Starting dose: Often initiated at 80mg daily for 4 weeks, then increased to 100mg daily based on tolerability.
4. Continue long-term therapy as directed—liver improvement may take 6–12 months.
5. Monitor liver enzymes and lipid profile regularly.

When Not to Use (RESMIROM 100MG TABLETS):

Do not use if you have:

1. Hypersensitivity to resmetirom
2. Severe hepatic impairment (Child-Pugh C)
3. Uncontrolled hyperthyroidism
4. Pregnancy or breastfeeding (safety not established)

Side Effects of (RESMIROM 100MG TABLETS):

Common:

1. Diarrhea, nausea, abdominal pain
2. Mild increase in heart rate (typically <5 bpm)
3. Transient elevations in liver enzymes (usually asymptomatic)

Rare/Serious:

1. Gallstone formation (due to enhanced cholesterol metabolism)
2. Muscle-related symptoms (myalgia, elevated CK—monitor if symptomatic)
3. Thyroid function changes (rare; monitor TSH if symptomatic)
4. Discontinue if signs of cholelithiasis (right upper quadrant pain, jaundice) occur.

Dosage: (RESMIROM 100MG TABLETS):

1. Maintenance dose: 100mg once daily with food
2. Titration: Start at 80mg/day for 4 weeks, then escalate to 100mg/day
3. Missed dose: Skip if >6 hours late—do not double dose
4. Elderly or renal impairment: No dose adjustment needed

Who It’s For (RESMIROM 100MG TABLETS):

Adults with biopsy-proven or clinically diagnosed NASH and liver fibrosis stage F2–F3, especially those with metabolic syndrome, obesity, or type 2 diabetes.

Warnings & Precautions:

1. Confirm NASH diagnosis before initiation (via FibroScan, ELF test, or biopsy)
2. Assess gallbladder status if abdominal pain develops
3. Monitor ALT, AST, CK, and lipids at baseline and periodically
4. Not a substitute for weight loss, diet, or exercise—use as part of comprehensive management

Drug Interactions:

1. Statins: May enhance LDL-lowering effect (generally beneficial)
2. Strong CYP2C9 inducers (e.g., rifampin): May reduce resmetirom levels
3. No significant interactions with common diabetes or antihypertensive drugs
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Available by prescription only in Pakistan (likely through specialty pharmacies or hepatology centers).