Product Information:

RAZODEX 60mg Capsules contain Rabeprazole Sodium 60mg, a high-strength proton pump inhibitor (PPI) that provides potent and prolonged suppression of gastric acid secretion by irreversibly inhibiting the H⁺/K⁺ ATPase enzyme (proton pump) in gastric parietal cells. This dose is reserved for severe, refractory, or hypersecretory acid-related conditions, particularly Zollinger-Ellison syndrome.

⚠️ Important Note:

While rabeprazole 20–30mg is standard for most indications, 60mg formulations are uncommon and typically used only in specific high-acid states under specialist supervision. Always confirm the indication and dosage with your physician.

Uses of (RAZODEX 60MG CAPSULES):

1. Zollinger-Ellison syndrome (gastrinoma) – where extreme gastric acid hypersecretion occurs
2. Severe, treatment-resistant GERD with complications (e.g., Barrett’s esophagus, strictures)
3. Refractory peptic ulcer disease unresponsive to standard PPI therapy
4. Short-term use in acute stress ulcer prophylaxis in critical care (off-label)

Key Benefits of (RAZODEX 6 0MG CAPSULES):

1. Maximum acid suppression for severe hypersecretory states
2. May reduce need for multiple daily doses in select cases
3. Promotes healing in complex or non-healing ulcers

How To Use (RAZODEX 60MG CAPSULES):

1. Take once daily, 30–60 minutes before breakfast (or first meal).
2. Swallow whole with water—do not crush, chew, or open the capsule.
3. Duration: Only for short-term use under gastroenterologist supervision.
4. Not for routine heartburn or mild GERD.

When Not to Use (RAZODEX 60MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to rabeprazole or other PPIs
2. Concurrent use of atazanavir or rilpivirine (HIV medications)
3. Uninvestigated dyspepsia (to avoid masking gastric cancer)
4. Severe liver disease (dose adjustment required)

Side Effects of (RAZODEX 60MG CAPSULES):

Common: Headache, diarrhea, abdominal pain, nausea.

Rare: Rash, dizziness, vitamin B12/magnesium deficiency.

Serious (more likely with high-dose/long-term use):

1. Clostridioides difficile infection
2. Osteoporosis-related fractures (hip, wrist, spine)
3. Hypomagnesemia (muscle spasms, arrhythmias, seizures)
4. Acute interstitial nephritis
5. Discontinue and seek medical help if severe symptoms occur.

Dosage Guidance:

1. Zollinger-Ellison syndrome: 60mg once daily (may increase up to 120mg/day in divided doses)
2. Other indications: Typically 30mg twice daily is preferred over 60mg once daily for better pH control
3. Elderly or hepatic impairment: Start with lower doses (e.g., 30mg/day)

Who It’s For (RAZODEX 60MG CAPSULES):

Adults with diagnosed acid-hypersecretory disorders under specialist care. Not for general use or self-medication.

Warnings & Precautions:

1. Avoid long-term use without medical supervision
2. Monitor magnesium, B12, kidney function, and bone health if used >8 weeks
3. Rule out gastric malignancy before initiating high-dose PPI therapy
4. Do not combine with atazanavir or rilpivirine

Drug Interactions:

1. Atazanavir, rilpivirine: ↓ Absorption—avoid concomitant use
2. Methotrexate: ↑ Toxicity risk
3. Clopidogrel: Rabeprazole has minimal interaction (safer than omeprazole)
4. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Use only as prescribed. Available by prescription in Pakistan.