Product Information:

RAZODEX 30mg Capsules contain Rabeprazole Sodium 30mg, a proton pump inhibitor (PPI) that provides potent and long-lasting suppression of gastric acid secretion by irreversibly inhibiting the H⁺/K⁺ ATPase enzyme (proton pump) in gastric parietal cells. This higher-strength formulation is used for moderate to severe acid-related disorders or conditions requiring intensified acid control.

Uses of (RAZODEX 30MG CAPSULES):

1. Treatment of severe gastroesophageal reflux disease (GERD) with erosive esophagitis
2. Healing and maintenance of refractory gastric or duodenal ulcers
3. Management of Zollinger-Ellison syndrome (gastrin-secreting tumors)
4. Helicobacter pylori eradication (as part of high-dose triple or quadruple therapy)
5. Prevention of NSAID-induced ulcers in high-risk patients

Key Benefits of (RAZODEX 30MG CAPSULES):

1. Stronger acid suppression than standard 20mg doses
2. Promotes faster healing of severe esophageal or gastric lesions
3. Once-daily dosing for improved adherence
4. Effective in conditions unresponsive to lower PPI doses

How To Use (RAZODEX 30MG CAPSULES):

1. Take once daily, preferably 30–60 minutes before breakfast (or first meal of the day).
2. Swallow whole with water—do not crush, chew, or open the capsule (enteric-coated granules may be damaged).
3. For H. pylori eradication: May be used as 30mg twice daily with antibiotics for 10–14 days (per local guidelines).
4. Duration: Typically 4–8 weeks; longer only under medical supervision.

When Not to Use (RAZODEX 30MG CAPSULES):

Do not use if you have:

1. Hypersensitivity to rabeprazole or other benzimidazole PPIs (e.g., omeprazole, pantoprazole)
2. Concurrent use of atazanavir or rilpivirine (PPIs significantly reduce their absorption)
3. Severe hepatic impairment (use with caution; consider lower dose)

Side Effects of (RAZODEX 30MG CAPSULES):

Common: Headache, diarrhea, abdominal pain, nausea, flatulence, constipation.

Rare: Dizziness, rash, dry mouth, vitamin B12 or magnesium deficiency (with prolonged use).

Serious (rare, usually with long-term use >1 year):

1. Clostridioides difficile-associated diarrhea
2. Increased risk of osteoporosis-related fractures (hip, wrist, spine)
3. Hypomagnesemia (muscle spasms, seizures, arrhythmias)
4. Acute interstitial nephritis (fever, rash, reduced urine output)
5. Discontinue and seek medical help if severe diarrhea, bone pain, or irregular heartbeat occurs.

Dosage: (RAZODEX 30MG CAPSULES):

1. Severe GERD / Erosive Esophagitis: 30mg once daily for 4–8 weeks
2. Zollinger-Ellison Syndrome: 60mg once daily (may split into two 30mg doses)
3. H. pylori Eradication: 30mg twice daily + two antibiotics for 10–14 days
4. NSAID Ulcer Prophylaxis (high-risk): 30mg once daily
5. Elderly or mild hepatic impairment: No routine adjustment needed

Who It’s For (RAZODEX 30MG CAPSULES):

Adults with severe or treatment-resistant acid-related disorders, including erosive esophagitis, Zollinger-Ellison syndrome, or those failing lower-dose PPI therapy.

Warnings & Precautions:

1. Use the lowest effective dose for the shortest duration necessary
2. Long-term use (>1 year) requires monitoring of serum magnesium, vitamin B12, and bone mineral density
3. May mask symptoms of gastric malignancy—investigate persistent dyspepsia
4. Avoid in patients on atazanavir or rilpivirine (HIV medications)

Drug Interactions:

1. Atazanavir, rilpivirine: ↓ Absorption—contraindicated
2. Clopidogrel: Rabeprazole has minimal interaction (safer than omeprazole)
3. Methotrexate: PPIs may ↑ toxicity—monitor levels
4. Iron, ketoconazole, digoxin: Altered absorption due to increased gastric pH
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.