Product Information:

PANTRA PLUS Tablets are a fixed-dose combination containing:

1. Pantoprazole 40mg – a proton pump inhibitor (PPI) that suppresses gastric acid production
2. Domperidone 30mg – a dopamine D2-receptor antagonist that enhances gastric motility and reduces nausea

This dual-action formulation is designed to manage acid-related disorders with associated dyspepsia, bloating, or delayed gastric emptying, such as gastroesophageal reflux disease (GERD), functional dyspepsia, and gastritis.

⚠️ Important Safety Note:

Domperidone carries a risk of cardiac arrhythmias (QT prolongation), especially at high doses or in patients with cardiac risk factors. Use the lowest effective dose for the shortest duration (typically ≤1 week). Not recommended in patients >60 years or with pre-existing heart conditions unless benefits outweigh risks.

Uses of (PANTRA PLUS TABLETS):

1. Treatment of GERD with associated bloating, early satiety, or nausea
2. Management of functional dyspepsia (indigestion with fullness, belching, upper abdominal discomfort)
3. Relief of gastritis with delayed gastric emptying
4. Adjunct in post-meal discomfort and regurgitation

Key Benefits of (PANTRA PLUS TABLETS):

1. Dual mechanism: Acid suppression + prokinetic action
2. Faster relief of bloating, nausea, and postprandial fullness compared to PPI alone
3. Once-daily dosing for convenience
4. Effective in patients with overlapping acid and motility symptoms

How To Use (PANTRA PLUS TABLETS):

1. Take one tablet once daily, preferably 30–60 minutes before breakfast.
2. Swallow whole with water—do not crush or chew.
3. Duration: Short-term use only (5–7 days) unless directed otherwise by a physician.
4. Avoid long-term domperidone use due to cardiac safety concerns.

When Not to Use (PANTRA PLUS TABLETS):

Do not use if you have:

1. Known hypersensitivity to pantoprazole or domperidone
2. Prolactinoma or pituitary tumor
3. Moderate to severe hepatic impairment
4. Cardiac conduction abnormalities (e.g., QT prolongation, heart failure, arrhythmias)
5. Concomitant use of QT-prolonging drugs (e.g., erythromycin, fluconazole, amiodarone)
6. History of gastrointestinal hemorrhage, obstruction, or perforation

Side Effects of (PANTRA PLUS TABLETS):

Common: Headache, diarrhea, dry mouth, dizziness, abdominal pain.

Less common: Galactorrhea (due to elevated prolactin), menstrual irregularities, restlessness.

Serious (rare but require monitoring):

1. QT prolongation → torsades de pointes (palpitations, syncope)
2. Extrapyramidal symptoms (especially in young women or high doses)
3. Hypomagnesemia (with prolonged PPI use)
4. Discontinue and seek medical help if chest palpitations, fainting, or involuntary muscle movements occur.

Dosage: (PANTRA PLUS TABLETS):

1. Adults: One tablet (40mg pantoprazole + 30mg domperidone) once daily before breakfast
2. Maximum duration: 7 days without medical review
3. Elderly (>60 years): Avoid unless strongly indicated and cardiac risk assessed
4. Not for children <12 years

Who It’s For (PANTRA PLUS TABLETS):

Adults with GERD or dyspepsia accompanied by bloating, nausea, or slow digestion, who require both acid control and gastric motility enhancement—preferably for short-term symptomatic relief.

Warnings & Precautions:

1. Avoid in patients with known heart disease or electrolyte imbalances
2. Do not exceed recommended dose or duration
3. Monitor for signs of arrhythmia (palpitations, dizziness, fainting)
4. Rule out organic causes (e.g., ulcer, malignancy) in persistent dyspepsia
5. Pantoprazole component may mask gastric cancer symptoms

Drug Interactions:

1. QT-prolonging drugs: ↑ Risk of arrhythmias—avoid combination
2. Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): ↑ Domperidone levels
3. Antacids: May reduce domperidone absorption—administer 2 hours apart
4. Warfarin, methotrexate: Pantoprazole may alter levels
5. Always inform your doctor about all medications.

Additional Information:

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiration date. Available by prescription in Pakistan.