Product Information:

ONSEGET Ampules 4mg/2mL contain Ondansetron 4mg in a sterile aqueous solution for intravenous (IV) or intramuscular (IM) injection. Ondansetron is a selective 5-HT₃ receptor antagonist that blocks serotonin receptors in the gut and brain, effectively preventing and treating nausea and vomiting.

This lower-strength injectable formulation is commonly used for mild to moderate emetogenic triggers, pediatric dosing, or in patients requiring reduced doses due to comorbidities.

Uses of (ONSEGET Ampules 4MG/2ML):

1. Prevention of postoperative nausea and vomiting (PONV)
2. Management of mild to moderate chemotherapy-induced nausea and vomiting (CINV)
3. Control of radiotherapy-induced nausea
4. Rescue therapy for acute vomiting unresponsive to oral antiemetics
5. Pediatric antiemetic use (dose adjusted by weight)

Key Benefits of (ONSEGET Ampules 4MG/2ML):

1. Rapid onset: IV effect within 2–5 minutes
2. Flexible dosing for adults and children
3. Lower strength allows precise titration in sensitive patients
4. Minimal sedation or anticholinergic side effects

How To Use (ONSEGET Ampules 4MG/2ML):

1. Administered by a healthcare professional via slow IV injection or IM injection.
2. IV route: Inject 4mg over at least 15 seconds (or dilute in 50mL saline and infuse over 15 minutes).
3. Standard adult dose:
4. PONV: 4mg IV/IM before end of surgery
5. Mild CINV: 4mg every 8 hours as needed
6. Pediatric dose: 0.1 mg/kg/dose (max 4mg per dose), every 4–6 hours if needed
7. Maximum daily dose (adults): 16–24mg (depending on indication)

When Not to Use (ONSEGET Ampules 4MG/2ML):

Do not use if you have:

1. Hypersensitivity to ondansetron or any excipients
2. Concurrent use of apomorphine (risk of severe hypotension)
3. Congenital long QT syndrome
4. Severe hepatic impairment (dose reduction required)

⚠️ Caution: Use carefully in patients with electrolyte imbalances (hypokalemia, hypomagnesemia) or on other QT-prolonging medications.

Side Effects of (ONSEGET Ampules 4MG/2ML):

Common: Headache, constipation, dizziness, mild flushing.

Less common: Injection site discomfort, transient hypotension (if injected too rapidly).

Serious (rare):

1. QT prolongation → risk of torsades de pointes (especially with rapid IV push or cardiac risk factors)
2. Serotonin syndrome (with SSRIs/SNRIs—symptoms: agitation, tremor, hyperthermia)
3. Discontinue and seek help if palpitations, fainting, or muscle rigidity occur.

Dosage: (ONSEGET Ampules 4MG/2ML):

1. Adults: 4mg IV/IM as single dose or every 8 hours
2. Children (≥6 months): 0.1 mg/kg/dose (max 4mg), every 4–6 hours
3. Elderly or hepatic impairment: Reduce frequency; max 8mg/day in severe liver disease

Who It’s For (ONSEGET Ampules 4MG/2ML):

1. Adults undergoing minor surgery or mild chemotherapy
2. Children with acute gastroenteritis or postoperative vomiting
3. Elderly or frail patients requiring lower-dose antiemetic therapy

Warnings & Precautions:

1. Inject slowly IV to avoid transient hypotension or headache
2. Correct electrolyte imbalances before administration
3. Monitor for serotonin syndrome if used with antidepressants
4. Does not treat underlying cause—use for symptomatic relief only

Drug Interactions:

1. Apomorphine: Contraindicated—causes profound hypotension
2. SSRIs/SNRIs (e.g., fluoxetine, sertraline): ↑ Risk of serotonin syndrome
3. QT-prolonging drugs (e.g., erythromycin, amiodarone): ↑ Arrhythmia risk
4. Always inform your doctor about all medications.

Additional Information:

Store below 25°C, protected from light. Do not freeze. Discard if discolored or contains particles. Keep out of reach of children. For clinical use only. Available by prescription in Pakistan.