Product Information:

ONSEGET Ampoule 8mg/4mL contains Ondansetron 8mg in a sterile aqueous solution for intravenous (IV) or intramuscular (IM) injection. Ondansetron is a potent and selective 5-HT₃ receptor antagonist that blocks serotonin both peripherally (in the gut) and centrally (in the chemoreceptor trigger zone), providing rapid control of nausea and vomiting.

This injectable formulation is used in hospital or clinical settings for acute or high-risk emetogenic situations.

Uses of (ONSEGET Ampoule 8MG/4ML):

1. Prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)
2. Control of radiotherapy-induced nausea and vomiting
3. Management of postoperative nausea and vomiting (PONV)
4. Rescue therapy for severe acute vomiting unresponsive to oral antiemetics

Key Benefits of (ONSEGET Ampoule 8MG/4ML):

1. Rapid onset: IV administration works within 2–5 minutes
2. High efficacy against moderate to highly emetogenic chemotherapy (e.g., cisplatin, doxorubicin)
3. Flexible routes: IV (preferred) or IM
4. Well-tolerated with minimal sedation or anticholinergic effects

How To Use (ONSEGET Ampoule 8MG/4ML):

1. Administered by a healthcare professional via slow IV injection or IM injection.
2. IV route: Inject 8mg over at least 15 seconds (or dilute in 50mL saline and infuse over 15 minutes for better tolerability).
3. Standard adult dose:
4. CINV: 8mg IV/IM 30 min before chemo, then every 8–12 hours for 1–2 days
5. PONV: 8mg IV/IM before end of surgery
6. Rescue: 8mg IV as needed (max 24mg/24h in adults)
7. Hepatic impairment: Max 8mg total per day

When Not to Use (ONSEGET Ampoule 8MG/4ML):

Do not use if you have:

1. Hypersensitivity to ondansetron or any excipients
2. Concurrent use of apomorphine (risk of profound hypotension and loss of consciousness)
3. Known congenital long QT syndrome
4. Severe hepatic impairment (dose adjustment required)

⚠️ ECG caution: Avoid in patients with baseline QT prolongation, electrolyte imbalances (hypokalemia, hypomagnesemia), or on other QT-prolonging drugs.

Side Effects of (ONSEGET Ampoule 8MG/4ML):

Common: Headache, constipation, dizziness, flushing, mild injection site reaction.

Less common: Hypotension (if injected too rapidly), transient ECG changes.

Serious (rare):

1. QT interval prolongation → risk of torsades de pointes (especially with rapid IV push or high doses)
2. Serotonin syndrome (if combined with SSRIs/SNRIs—symptoms: agitation, tremor, hyperthermia)
3. Extrapyramidal symptoms (very rare)
4. Discontinue and seek help if palpitations, syncope, or muscle rigidity occur.

Dosage: (ONSEGET Ampoule 8MG/4ML):

1. Adults:
2. Single dose: 8mg IV/IM
3. Max daily dose: 24mg (in divided doses)
4. Severe liver disease: Max 8mg/day
5. Children: Use only under specialist guidance; lower doses based on weight

Who It’s For (ONSEGET Ampoule 8MG/4ML):

Hospitalized adults undergoing chemotherapy, major surgery, or suffering from severe acute vomiting requiring rapid antiemetic control.

Warnings & Precautions:

1. Inject slowly IV—rapid administration may cause flushing, headache, or transient hypotension
2. Correct electrolyte imbalances before use
3. Monitor ECG in high-risk cardiac patients
4. Does not treat underlying cause of vomiting—use for symptomatic relief only

Drug Interactions:

1. Apomorphine: Contraindicated—causes severe hypotension
2. SSRIs/SNRIs (e.g., fluoxetine, venlafaxine): ↑ Risk of serotonin syndrome
3. Other QT-prolonging drugs (e.g., amiodarone, erythromycin): ↑ Arrhythmia risk
4. Always inform your doctor about all medications.

Additional Information:

Store below 25°C, protected from light. Do not freeze. Discard if discolored or contains particles. Keep out of reach of children. For hospital or clinical use only. Available by prescription in Pakistan.